PMID- 23853557
OWN - NLM
STAT- MEDLINE
DCOM- 20140314
LR  - 20211021
IS  - 1550-9397 (Electronic)
IS  - 1550-9389 (Print)
IS  - 1550-9389 (Linking)
VI  - 9
IP  - 7
DP  - 2013 Jul 15
TI  - Serum brain-derived neurotrophic factor levels are associated with dyssomnia in 
      females, but not males, among Japanese workers.
PG  - 649-54
LID - 10.5664/jcsm.2828 [doi]
AB  - STUDY OBJECTIVES: Brain-derived neurotrophic factor (BDNF) is a member of the 
      neurotrophin family of growth factors that promote the growth and survival of 
      neurons. Recent evidence suggests that BDNF is a sleep regulatory substance that 
      contributes to sleep behavior. However, no studies have examined the association 
      between the serum BDNF levels and dyssomnia. The present study was conducted to 
      clarify the association between the serum BDNF levels and dyssomnia. METHODS: A 
      total of 344 workers (age: 40.1 +/- 10.5 years, male: 204, female: 140) were 
      included in the study. The serum BDNF levels were categorized into tertiles 
      according to sex. RESULTS: The prevalence of dyssomnia was 35.1% in males and 
      30.0% in females. In the females, the BDNF levels were found to be negatively 
      associated with dyssomnia after adjusting for age, body mass index, hypertension, 
      dyslipidemia, hyperglycemia, depression, smoking, alcohol intake, and regular 
      exercise. Compared with the females in the high BDNF group, the multivariate odds 
      ratio (95% CI) of dyssomnia was 2.08 (0.62-6.98) in females in the moderate BDNF 
      group and 8.41 (2.05-27.14) in females in the low BDNF group. No such 
      relationships were found in the males. CONCLUSIONS: The serum BDNF levels are 
      associated with dyssomnia in Japanese female, but not male, workers.
FAU - Nishichi, Reiko
AU  - Nishichi R
AD  - Department of Community Health Nursing, Shimane University Faculty of Medicine, 
      Izumo, Shimane, 693-8501, Japan. rei130@lime.ocn.ne.jp
FAU - Nufuji, Yu
AU  - Nufuji Y
FAU - Washio, Masakazu
AU  - Washio M
FAU - Kumagai, Shuzo
AU  - Kumagai S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130715
PL  - United States
TA  - J Clin Sleep Med
JT  - Journal of clinical sleep medicine : JCSM : official publication of the American 
      Academy of Sleep Medicine
JID - 101231977
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Dyssomnias/*blood
MH  - *Employment
MH  - Female
MH  - Humans
MH  - Japan
MH  - Male
MH  - Odds Ratio
MH  - Sex Factors
PMC - PMC3671328
OTO - NOTNLM
OT  - Japanese worker
OT  - Serum brain-derived neurotrophic factor
OT  - dyssomnia
OT  - sex
EDAT- 2013/07/16 06:00
MHDA- 2014/03/15 06:00
PMCR- 2014/01/15
CRDT- 2013/07/16 06:00
PHST- 2013/07/16 06:00 [entrez]
PHST- 2013/07/16 06:00 [pubmed]
PHST- 2014/03/15 06:00 [medline]
PHST- 2014/01/15 00:00 [pmc-release]
AID - 10.5664/jcsm.2828 [doi]
PST - epublish
SO  - J Clin Sleep Med. 2013 Jul 15;9(7):649-54. doi: 10.5664/jcsm.2828.