PMID- 23856275
OWN - NLM
STAT- MEDLINE
DCOM- 20150922
LR  - 20240506
IS  - 1749-8090 (Electronic)
IS  - 1749-8090 (Linking)
VI  - 8
DP  - 2013 Jul 15
TI  - Obesity and the risk of late mortality after aortic valve replacement with small 
      prosthesis.
PG  - 174
LID - 10.1186/1749-8090-8-174 [doi]
AB  - BACKGROUND: Whether obesity is related to late mortality with implantation of 
      small aortic prosthesis remains to be clarified. This study was aimed to evaluate 
      the effect of obesity on late survival of patients after aortic valve replacement 
      (AVR) with implantation of small aortic prosthesis (size </= 21 mm). METHODS: From 
      January 1998 to December 2008, 307 patients in our institution who underwent 
      primary AVR with smaller prostheses survived the 30 days after surgery. Patients 
      were defined as normal if body mass index (BMI) was < 24 kg/m2, as overweight if 
      BMI 24-27.9 kg/m2, and as obese if BMI >/= 28 kg/m2. Data of New York Heart 
      Association (NYHA) functional classification, left ventricular ejection fraction 
      (LVEF), effective orifice area index (EOAI), and left ventricular mass index 
      (LVMI) of the patients collected at the 3rd month (M), 6th M, 1st year (Y), 3rd 
      Y, 5th Y, 8th Y after operation respectively. RESULTS: By multivariable analysis, 
      obesity was an independent factor of late mortality (hazard ratio [HR]: 1.62; 
      P = 0.01). The obesity and overweight group had more poor survival (p < 0.001) 
      and higher proportion of NYHA class III/IV (p < 0.01) compared with the normal 
      group. Lower EOAI and higher LVMI were found in obesity and overweight group, but 
      we saw no significant difference about LVEF among the three groups. CONCLUSIONS: 
      Obesity was associated with increased late mortality of patients after AVR with 
      implantation of small aortic prosthesis. Being obese or and overweight may also 
      affect the NYHA classification, even in the longer term. EOAI should be improved 
      where possible, as it may reduce late mortality and improve quality of life in 
      obese or overweight patients.
FAU - Wang, Biao
AU  - Wang B
FAU - Yang, Hongyang
AU  - Yang H
FAU - Wu, Shuming
AU  - Wu S
FAU - Cao, Guangqing
AU  - Cao G
FAU - Yang, Hongling
AU  - Yang H
LA  - eng
PT  - Journal Article
DEP - 20130715
PL  - England
TA  - J Cardiothorac Surg
JT  - Journal of cardiothoracic surgery
JID - 101265113
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aortic Valve/*surgery
MH  - Body Mass Index
MH  - China
MH  - Female
MH  - Heart Valve Prosthesis
MH  - Heart Valve Prosthesis Implantation/*mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/*complications
MH  - Prospective Studies
MH  - Quality of Life
MH  - Risk Factors
MH  - Survival Rate
MH  - Ventricular Function, Left
PMC - PMC3765481
EDAT- 2013/07/17 06:00
MHDA- 2015/09/24 06:00
PMCR- 2013/07/15
CRDT- 2013/07/17 06:00
PHST- 2012/11/11 00:00 [received]
PHST- 2013/06/25 00:00 [accepted]
PHST- 2013/07/17 06:00 [entrez]
PHST- 2013/07/17 06:00 [pubmed]
PHST- 2015/09/24 06:00 [medline]
PHST- 2013/07/15 00:00 [pmc-release]
AID - 1749-8090-8-174 [pii]
AID - 10.1186/1749-8090-8-174 [doi]
PST - epublish
SO  - J Cardiothorac Surg. 2013 Jul 15;8:174. doi: 10.1186/1749-8090-8-174.