PMID- 2385646
OWN - NLM
STAT- MEDLINE
DCOM- 19900920
LR  - 20190712
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 47
IP  - 4
DP  - 1990 Apr
TI  - Alcohol-preferring rats: genetic sensitivity to alcohol-induced stimulation of 
      dopamine metabolism.
PG  - 727-9
AB  - The effect of ethanol on brain dopamine (DA) metabolism in the caudate nucleus 
      (CN), olfactory tubercle (OT) and medial prefrontal cortex (MPFC) was compared in 
      two selectively bred rat lines, one ethanol preferring and the other ethanol 
      nonpreferring. Male rats from the 16th and 17th generations of both lines that 
      never experienced ethanol beforehand were used. No differences in the basal 
      concentrations of DA and its metabolites, DOPAC and HVA, in the above brain 
      regions were found between the two lines. The oral administration of 2 g/kg of 
      ethanol to ethanolnonpreferring rats increased DOPAC and HVA and reduced DA 
      levels in the CN and OT but was ineffective in the MPFC. On the other hand, 
      ethanol administration to ethanol-preferring rats decreased DA content and 
      increased DOPAC and HVA levels, not only in the CN and OT, but also in the MPFC. 
      Moreover, the changes induced by ethanol on DA metabolism in the latter group 
      were significantly greater than in ethanol nonpreferring rats. These results 
      indicate that ethanol preferring rats have a genetic high sensitivity to the 
      ethanol effect on DA metabolism, and suggest that such a trait might play a role 
      in ethanol preference.
FAU - Fadda, F
AU  - Fadda F
AD  - Department of Neurosciences, University of Cagliari, Italy.
FAU - Mosca, E
AU  - Mosca E
FAU - Colombo, G
AU  - Colombo G
FAU - Gessa, G L
AU  - Gessa GL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Receptors, Dopamine)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - VTD58H1Z2X (Dopamine)
RN  - X77S6GMS36 (Homovanillic Acid)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/metabolism
MH  - Alcohol Drinking/*physiology
MH  - Animals
MH  - Arousal/*drug effects
MH  - Brain Mapping
MH  - Caudate Nucleus/*drug effects
MH  - Dopamine/*physiology
MH  - Frontal Lobe/*drug effects
MH  - Homovanillic Acid/metabolism
MH  - Male
MH  - Motivation
MH  - Neural Pathways/drug effects
MH  - Olfactory Bulb/*drug effects
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Dopamine/*genetics
MH  - *Species Specificity
EDAT- 1990/04/01 00:00
MHDA- 1990/04/01 00:01
CRDT- 1990/04/01 00:00
PHST- 1990/04/01 00:00 [pubmed]
PHST- 1990/04/01 00:01 [medline]
PHST- 1990/04/01 00:00 [entrez]
AID - 0031-9384(90)90085-I [pii]
AID - 10.1016/0031-9384(90)90085-i [doi]
PST - ppublish
SO  - Physiol Behav. 1990 Apr;47(4):727-9. doi: 10.1016/0031-9384(90)90085-i.