PMID- 23857776
OWN - NLM
STAT- MEDLINE
DCOM- 20140724
LR  - 20161128
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 38
IP  - 6
DP  - 2013 Dec
TI  - Modeling DCE-MRI at low temporal resolution: a case study on rheumatoid 
      arthritis.
PG  - 1554-63
LID - 10.1002/jmri.24061 [doi]
AB  - PURPOSE: To identify the optimal tracer-kinetic modeling strategy for dynamic 
      contrast-enhanced magnetic resonance imaging (DCE-MRI) data acquired at low 
      temporal resolution. MATERIALS AND METHODS: DCE-MRI was performed on 13 patients 
      with rheumatoid arthritis of the hand before and after anti-tumor necrosis factor 
      alpha (TNFalpha) therapy, using a 3D sequence with a temporal resolution of 13 
      seconds, imaging for 4 minutes postcontrast injection. Concentration-time curves 
      were extracted from regions of interest (ROIs) in enhancing synovium and fitted 
      to the 3-parameter modified Tofts model (MT) and the 4-parameter two-compartment 
      exchange model (2CXM). To assist the interpretation of the data, the same 
      analysis was applied to simulated data with similar characteristics. RESULTS: 
      Both models fitted the data closely, and showed similar therapy effects. The MT 
      plasma volume was significantly lower than with 2CXM, but the differences in 
      permeability and interstitial volume were not significant. 2CXM was less precise 
      than MT, with larger standard deviations relative to the mean in most parameters. 
      The additional perfusion parameter determined with 2CXM did not provide a 
      statistically significant trend due to low precision. CONCLUSION: The standard MT 
      model is the optimal modeling strategy at low temporal resolution. Advanced 
      models improve the accuracy and generate an additional parameter, but these 
      benefits are offset by low precision.
CI  - Copyright (c) 2013 Wiley Periodicals, Inc.
FAU - Ledsam, Joseph R
AU  - Ledsam JR
AD  - Division of Medical Physics, University of Leeds, Leeds, UK.
FAU - Hodgson, Richard
AU  - Hodgson R
FAU - Moots, Robert J
AU  - Moots RJ
FAU - Sourbron, Steven P
AU  - Sourbron SP
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20130715
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
RN  - 0 (Heterocyclic Compounds)
RN  - 0 (Organometallic Compounds)
RN  - 99J2XUF1JT (gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate)
SB  - IM
MH  - Algorithms
MH  - Arthritis, Rheumatoid/*diagnosis/*metabolism
MH  - Computer Simulation
MH  - Female
MH  - Heterocyclic Compounds/*pharmacokinetics
MH  - Humans
MH  - Image Enhancement/methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - *Models, Biological
MH  - Organometallic Compounds/*pharmacokinetics
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
OTO - NOTNLM
OT  - MRI
OT  - Tofts model
OT  - dynamic contrast-enhanced
OT  - perfusion
OT  - permeability
OT  - rheumatoid arthritis
OT  - tracer kinetics
OT  - two-compartment model
EDAT- 2013/07/17 06:00
MHDA- 2014/07/25 06:00
CRDT- 2013/07/17 06:00
PHST- 2012/06/05 00:00 [received]
PHST- 2013/01/10 00:00 [accepted]
PHST- 2013/07/17 06:00 [entrez]
PHST- 2013/07/17 06:00 [pubmed]
PHST- 2014/07/25 06:00 [medline]
AID - 10.1002/jmri.24061 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2013 Dec;38(6):1554-63. doi: 10.1002/jmri.24061. Epub 2013 
      Jul 15.