PMID- 2385831
OWN - NLM
STAT- MEDLINE
DCOM- 19900914
LR  - 20190727
IS  - 0049-3848 (Print)
IS  - 0049-3848 (Linking)
VI  - 58
IP  - 6
DP  - 1990 Jun 15
TI  - Dynamic aspects of thrombus formation in mutant analbuminemic rats.
PG  - 633-43
AB  - To elucidate the mechanism for thrombus formation in hypoalbuminemic and 
      hyperlipidemic subjects, the experimental thrombus formation was analyzed in 
      Nagase analbuminemic rats (NAR). The mutant rat reveals similar biochemical 
      findings to those of NS, such as hyperlipidemia. When thrombus was induced in a 
      small branch of the mesenteric artery by inserting a glass micropipette, thrombus 
      formation was observed within 4 min in NAR and Sprague-Dawley rat (SDR). In SDR, 
      the thrombus gradually grew up in size and detached from the inserted glass 
      micropipette within 4 min after its formation. In contrast, the thrombus formed 
      in NAR did not dissociate from the micropipette until 10-13 min after its 
      formation. The maximum size of the thrombus formed in NAR was about 4 times 
      larger than that in SDR. In the presence of fibrin, the plasma samples from NAR 
      inhibited the activity of tissue-plasminogen activator (t-PA) 1.7 times more 
      potently than did SDR plasma. Plasma gamma 2-plasmin inhibitor activity was 
      significantly higher than that in SDR. Albumin significantly enhanced the 
      t-PA-catalyzed activation of plasminogen, suggesting that the serum albumin might 
      contribute, at least in part, to the plasma fibrinolytic activity. Thus, the 
      higher thrombogenic potential in NAR than in SDR might be due to the reduced 
      thrombolytic activity in NAR.
FAU - Koga, S
AU  - Koga S
AD  - Department of Internal Medicine, Kumamoto University Medical School, Japan.
FAU - Okajima, K
AU  - Okajima K
FAU - Inoue, M
AU  - Inoue M
FAU - Okabe, H
AU  - Okabe H
FAU - Araki, H
AU  - Araki H
FAU - Nagase, S
AU  - Nagase S
FAU - Takatsuki, K
AU  - Takatsuki K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Thromb Res
JT  - Thrombosis research
JID - 0326377
RN  - 0 (Serum Albumin)
SB  - IM
MH  - Animals
MH  - Female
MH  - Humans
MH  - Platelet Aggregation/genetics
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Rats, Mutant Strains
MH  - Serum Albumin/*deficiency/genetics
MH  - Species Specificity
MH  - Thrombosis/*genetics
EDAT- 1990/06/15 00:00
MHDA- 1990/06/15 00:01
CRDT- 1990/06/15 00:00
PHST- 1990/06/15 00:00 [pubmed]
PHST- 1990/06/15 00:01 [medline]
PHST- 1990/06/15 00:00 [entrez]
AID - 10.1016/0049-3848(90)90309-z [doi]
PST - ppublish
SO  - Thromb Res. 1990 Jun 15;58(6):633-43. doi: 10.1016/0049-3848(90)90309-z.