PMID- 23859562
OWN - NLM
STAT- MEDLINE
DCOM- 20140220
LR  - 20130813
IS  - 1520-5827 (Electronic)
IS  - 0743-7463 (Linking)
VI  - 29
IP  - 32
DP  - 2013 Aug 13
TI  - beta-Amino acid and amino-alcohol conjugation of a nonsteroidal anti-inflammatory 
      drug (NSAID) imparts hydrogelation displaying remarkable biostability, 
      biocompatibility, and anti-inflammatory properties.
PG  - 10254-63
LID - 10.1021/la401929v [doi]
AB  - A well-known nonsteroidal anti-inflammatory drug (NSAID), namely, naproxen (Np), 
      was conjugated with beta-alanine and various combinations of amino alcohols and 
      l-alanine. Quite a few bioconjugates, thus synthesized, were capable of gelling 
      pure water, NaCl solution (0.9 wt %), and phosphate-buffered saline (PBS) (pH 
      7.4). The hydrogels were characterized by rheology and electron microscopy. 
      Hydrogelation was probed by FT-IR and temperature-variable (1)H NMR studies. 
      Single-crystal X-ray diffraction (SXRD) of a nonhydrogelator and a hydrogelator 
      in the series established a useful structure-property (gelation) correlation. MTT 
      assay of the hydrogelators in the mouse macrophage RAW 264.7 cell line showed 
      excellent biocompatibility. The prostaglandin E2 (PGE2) assay of the 
      hydrogelators revealed their anti-inflammatory response, which was comparable to 
      that of the parent NSAID naproxen sodium (Ns).
FAU - Majumder, Joydeb
AU  - Majumder J
AD  - Department of Organic Chemistry, Indian Association for the Cultivation of 
      Science, 2A & 2B Raja S. C. Mullick Road, Kolkata-700032, India.
FAU - Das, Mahua Rani
AU  - Das MR
FAU - Deb, Jolly
AU  - Deb J
FAU - Jana, Siddhartha Sankar
AU  - Jana SS
FAU - Dastidar, Parthasarathi
AU  - Dastidar P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130801
PL  - United States
TA  - Langmuir
JT  - Langmuir : the ACS journal of surfaces and colloids
JID - 9882736
RN  - 0 (Amino Acids)
RN  - 0 (Amino Alcohols)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Biocompatible Materials)
RN  - 0 (Hydrogels)
RN  - 0 (Lipopolysaccharides)
RN  - 82115-62-6 (Interferon-gamma)
RN  - K7Q1JQR04M (Dinoprostone)
SB  - IM
MH  - Amino Acids/*chemistry
MH  - Amino Alcohols/*chemistry
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/chemical 
      synthesis/chemistry/*pharmacology
MH  - Biocompatible Materials/*chemistry
MH  - Cell Line
MH  - Dinoprostone/antagonists & inhibitors/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Hydrogels/*chemistry
MH  - Interferon-gamma/antagonists & inhibitors/metabolism
MH  - Lipopolysaccharides/antagonists & inhibitors/pharmacology
MH  - Macrophages/drug effects/metabolism
MH  - Mice
MH  - Models, Molecular
MH  - Molecular Structure
MH  - Particle Size
MH  - Surface Properties
EDAT- 2013/07/19 06:00
MHDA- 2014/02/22 06:00
CRDT- 2013/07/18 06:00
PHST- 2013/07/18 06:00 [entrez]
PHST- 2013/07/19 06:00 [pubmed]
PHST- 2014/02/22 06:00 [medline]
AID - 10.1021/la401929v [doi]
PST - ppublish
SO  - Langmuir. 2013 Aug 13;29(32):10254-63. doi: 10.1021/la401929v. Epub 2013 Aug 1.