PMID- 23859870
OWN - NLM
STAT- MEDLINE
DCOM- 20140924
LR  - 20151119
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 17
IP  - 3
DP  - 2013 Nov
TI  - Geniposide inhibits airway inflammation and hyperresponsiveness in a mouse model 
      of asthma.
PG  - 561-7
LID - S1567-5769(13)00281-6 [pii]
LID - 10.1016/j.intimp.2013.06.028 [doi]
AB  - Our group recently reported the strong anti-inflammatory effects of geniposide 
      (Gen), a bioactive iridoid glucoside derived from gardenia jasminoides, in a 
      mouse acute lung injury model. Herein, we hypothesized that Gen might also have 
      potential therapeutic benefits in treatment of asthma, which was tested in a 
      mouse model of ovalbumin (Ova)-induced allergic airway inflammation. 
      Ova-sensitized and -challenged BALB/c mice, as compared with control animals, 
      displayed airway hyperresponsiveness (AHR), bronchoalveolar lavage eosinophilia, 
      mucus hypersecretion, and increased T help 2 (Th2)-associated cytokine and 
      chemokine amounts, as well as serum Ova-specific immunoglobulin E (IgE) level. 
      Being compared with the Ova-induced hallmarks of asthma, intraperitoneal Gen 
      treatment prevented eosinophilic pulmonary infiltration, attenuated the increases 
      in interleukin (IL)-4, IL-5, and IL-13, and reduced eotaxin and vascular cell 
      adhesion molecule 1 (VCAM-1) expression. Also, Gen significantly ameliorated the 
      Ova-driven airway hyperresponsiveness, mucus hypersecretion, and 
      allergen-specific IgE level, which are the cardinal pathophysiological symptoms 
      in allergic airway diseases. In addition, the efficacy of Gen was comparable to 
      that of dexamethasone (Dex), a currently available anti-asthmatic drug. 
      Collectively, our findings reveal that the development of immunoregulatory 
      strategies based on Gen may be considered as an effective adjuvant therapy for 
      allergic asthma.
CI  - (c) 2013. Published by Elsevier B.V. All rights reserved.
FAU - Deng, Yanhong
AU  - Deng Y
AD  - College of Veterinary Medicine, Jilin University, Changchun 130062, PR China.
FAU - Guan, Mingfeng
AU  - Guan M
FAU - Xie, Xingxing
AU  - Xie X
FAU - Yang, Xiaofeng
AU  - Yang X
FAU - Xiang, Hua
AU  - Xiang H
FAU - Li, Hongyu
AU  - Li H
FAU - Zou, Lianchun
AU  - Zou L
FAU - Wei, Jingyuan
AU  - Wei J
FAU - Wang, Dacheng
AU  - Wang D
FAU - Deng, Xuming
AU  - Deng X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130713
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Allergens)
RN  - 0 (Anti-Asthmatic Agents)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (Iridoids)
RN  - 145295QLXY (geniposide)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Allergens/immunology
MH  - Animals
MH  - Anti-Asthmatic Agents/pharmacology/*therapeutic use
MH  - Anti-Inflammatory Agents/pharmacology/*therapeutic use
MH  - Asthma/*drug therapy/immunology/pathology
MH  - Bronchial Hyperreactivity/*drug therapy/immunology/pathology
MH  - Bronchoalveolar Lavage Fluid/cytology/immunology
MH  - Cell Count
MH  - Cytokines/immunology
MH  - Disease Models, Animal
MH  - Female
MH  - Immunoglobulin E/blood
MH  - Iridoids/pharmacology/*therapeutic use
MH  - Lung/drug effects/pathology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/immunology
OTO - NOTNLM
OT  - Allergic airway inflammation
OT  - Asthma
OT  - Geniposide (Gen)
OT  - Hyperresponsiveness
OT  - Nuclear factor-kappaB (NF-kappaB)
OT  - Ovalbumin (Ova)
EDAT- 2013/07/19 06:00
MHDA- 2014/09/25 06:00
CRDT- 2013/07/18 06:00
PHST- 2012/11/24 00:00 [received]
PHST- 2013/06/21 00:00 [revised]
PHST- 2013/06/24 00:00 [accepted]
PHST- 2013/07/18 06:00 [entrez]
PHST- 2013/07/19 06:00 [pubmed]
PHST- 2014/09/25 06:00 [medline]
AID - S1567-5769(13)00281-6 [pii]
AID - 10.1016/j.intimp.2013.06.028 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2013 Nov;17(3):561-7. doi: 10.1016/j.intimp.2013.06.028. 
      Epub 2013 Jul 13.