PMID- 23859972
OWN - NLM
STAT- MEDLINE
DCOM- 20140312
LR  - 20130717
IS  - 1662-2804 (Electronic)
IS  - 0300-5186 (Linking)
VI  - 32
DP  - 2013
TI  - High voltage electric potentials to enhance brain-derived neurotrophic factor 
      levels in the brain.
PG  - 129-38
LID - 10.1159/000346422 [doi]
AB  - Development of a safe method to increase brain-derived neurotrophic factor (BDNF) 
      levels in the brain is expected to enhance learning and memory, induce tolerance 
      to cerebral infarction or tolerance to depressive state, improve glucose 
      metabolism, and suppress appetite and body weight. We have shown that repetitive 
      applications of high-voltage electric potential (HELP) to the body increase BDNF 
      levels in the brain, improving learning and memory in mice. Here, we investigated 
      the effects of HELP treatment for a chronic period on the BDNF levels in the 
      mouse brain, and on body weight in mice and humans. Adult mice were exposed to 
      3.1 or 5.4 kV HELP (on the body), 5 h a day for 24 weeks, and BDNF levels in the 
      brain and alterations in body weight were analyzed. Humans [age, 53.2 +/- 15.5 
      years old; BMI, 27.8 +/- 5.6 (mean +/- SD, n = 6)] were exposed to 3.9 kV HELP (on 
      the body) for 1 h a day, continuing for 33 months (2.8 years) under the monitor 
      of body weight. In mice, the HELP application elevated BDNF levels in the brain 
      at least temporarily, affecting body weight in a voltage- and time-dependent 
      manner. In humans, the HELP treatment reduced body weight compared to the 
      pretreated initial values without any aversive effects (p < 0.002, one-way ANOVA 
      with the post hoc Holm-Sidak test). The results in mice indicated that 3.1 kV 
      HELP was considered insufficient for a continuous elevation of intracerebral 
      BDNF, and 5.4 kV HELP was considered as excessive. HELP with an appropriate 
      voltage can be utilized to increase BDNF levels in the brain for a prolonged 
      period. We anticipate further investigations to clarify the effect of the 
      optimal-leveled HELP therapy on memory disturbances, neurological deficits after 
      stroke, depression, diabetes, obesity and metabolic syndrome.
CI  - Copyright (c) 2013 S. Karger AG, Basel.
FAU - Yanamoto, Hiroji
AU  - Yanamoto H
AD  - Laboratory of Neurology and Neurosurgery Osaka University Graduate School of 
      Medicine, 5-7-1 Fujishirodai, Suita, Japan. hyanamot@res.ncvc.go.jp
FAU - Nakajo, Yukako
AU  - Nakajo Y
FAU - Kataoka, Hiroharu
AU  - Kataoka H
FAU - Iihara, Koji
AU  - Iihara K
LA  - eng
PT  - Journal Article
DEP - 20130708
PL  - Switzerland
TA  - Front Neurol Neurosci
JT  - Frontiers of neurology and neuroscience
JID - 101274949
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Body Weight/*physiology
MH  - Brain Chemistry/*physiology
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis/metabolism/physiology
MH  - Electric Stimulation/*methods
MH  - Evoked Potentials/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Middle Aged
EDAT- 2013/07/19 06:00
MHDA- 2014/03/13 06:00
CRDT- 2013/07/18 06:00
PHST- 2013/07/18 06:00 [entrez]
PHST- 2013/07/19 06:00 [pubmed]
PHST- 2014/03/13 06:00 [medline]
AID - 000346422 [pii]
AID - 10.1159/000346422 [doi]
PST - ppublish
SO  - Front Neurol Neurosci. 2013;32:129-38. doi: 10.1159/000346422. Epub 2013 Jul 8.