PMID- 23860206
OWN - NLM
STAT- MEDLINE
DCOM- 20140211
LR  - 20211021
IS  - 1422-0067 (Print)
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 14
IP  - 7
DP  - 2013 Jul 15
TI  - Enhanced development of azoxymethane-induced colonic preneoplastic lesions in 
      hypertensive rats.
PG  - 14700-11
LID - 10.3390/ijms140714700 [doi]
AB  - Metabolic syndrome is associated with an increased risk of colorectal cancer. 
      This study investigated the impact of hypertension, a component of metabolic 
      syndrome, on azoxymethane (AOM)-induced colorectal carcinogenesis using SHRSP/Izm 
      (SHRSP) non-diabetic/hypertensive rats and SHRSP.Z-Leprfa/IzmDmcr (SHRSP-ZF) 
      diabetic/hypertensive rats. Male 6-week-old SHRSP, SHRSP-ZF, and control 
      non-diabetic/normotensive Wister Kyoto/Izm (WKY) rats were given 2 weekly 
      intraperitoneal injections of AOM (20 mg/kg body weight). Two weeks after the 
      last injection of AOM, the SHRSP and SHRSP-ZF rats became hypertensive compared 
      to the control WKY rats. Serum levels of angiotensin-II, the active product of 
      the renin-angiotensin system, were elevated in both SHRSP and SHRSP-ZF rats, but 
      only the SHRSP-ZF rats developed insulin resistance, dyslipidemia, and 
      hyperleptinemia and exhibited an increase in adipose tissue. The development of 
      AOM-induced colonic preneoplastic lesions and aberrant crypts foci, was 
      significantly accelerated in both SHRSP and SHRSP-ZF hypertensive rats, compared 
      to WKY normotensive rats. Furthermore, induction of oxidative stress and 
      exacerbation of inflammation were observed in the colonic mucosa and systemically 
      in SHRSP and SHRSP-ZF rats. Our findings suggest that hypertension plays a role 
      in the early stage of colorectal carcinogenesis by inducing oxidative stress and 
      chronic inflammation, which might be associated with activation of the 
      renin-angiotensin system.
FAU - Kochi, Takahiro
AU  - Kochi T
AD  - Department of Internal Medicine, Gifu University Graduate School of Medicine, 
      Gifu 501-1194, Japan.
FAU - Shimizu, Masahito
AU  - Shimizu M
FAU - Ohno, Tomohiko
AU  - Ohno T
FAU - Baba, Atsushi
AU  - Baba A
FAU - Sumi, Takafumi
AU  - Sumi T
FAU - Kubota, Masaya
AU  - Kubota M
FAU - Shirakami, Yohei
AU  - Shirakami Y
FAU - Tsurumi, Hisashi
AU  - Tsurumi H
FAU - Tanaka, Takuji
AU  - Tanaka T
FAU - Moriwaki, Hisataka
AU  - Moriwaki H
LA  - eng
PT  - Journal Article
DEP - 20130715
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Carcinogens)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 11128-99-7 (Angiotensin II)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
RN  - EC 1.14.99.1 (Cyclooxygenase 2)
RN  - MO0N1J0SEN (Azoxymethane)
SB  - IM
MH  - Adipose Tissue/metabolism
MH  - Angiotensin II/blood
MH  - Animals
MH  - Azoxymethane/*toxicity
MH  - Carcinogens/*toxicity
MH  - Catalase/genetics/metabolism
MH  - Chemokine CCL2/genetics/metabolism
MH  - Colorectal Neoplasms/*pathology
MH  - Cyclooxygenase 2/blood
MH  - Glutathione Peroxidase/genetics/metabolism
MH  - Hypertension/*pathology
MH  - Insulin Resistance
MH  - Interleukin-6/blood
MH  - Intestinal Mucosa/metabolism
MH  - Male
MH  - Nitric Oxide Synthase Type II/genetics/metabolism
MH  - Oxidative Stress/*drug effects
MH  - Precancerous Conditions
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Rats, Zucker
MH  - Tumor Necrosis Factor-alpha/blood/genetics/metabolism
PMC - PMC3742268
EDAT- 2013/07/19 06:00
MHDA- 2014/02/12 06:00
PMCR- 2013/07/01
CRDT- 2013/07/18 06:00
PHST- 2013/05/02 00:00 [received]
PHST- 2013/06/25 00:00 [revised]
PHST- 2013/06/27 00:00 [accepted]
PHST- 2013/07/18 06:00 [entrez]
PHST- 2013/07/19 06:00 [pubmed]
PHST- 2014/02/12 06:00 [medline]
PHST- 2013/07/01 00:00 [pmc-release]
AID - ijms140714700 [pii]
AID - ijms-14-14700 [pii]
AID - 10.3390/ijms140714700 [doi]
PST - epublish
SO  - Int J Mol Sci. 2013 Jul 15;14(7):14700-11. doi: 10.3390/ijms140714700.