PMID- 23861338
OWN - NLM
STAT- MEDLINE
DCOM- 20131024
LR  - 20191210
IS  - 1945-2403 (Electronic)
IS  - 0146-4760 (Linking)
VI  - 37
IP  - 7
DP  - 2013 Sep
TI  - Four fatalities involving 5-IT.
PG  - 447-51
LID - 10.1093/jat/bkt053 [doi]
AB  - The new designer drug 5-(2-aminopropyl)indole (5-IT) is an indole derivative with 
      stimulant properties. Its synthesis was first described by Albert Hofmann and 
      Franz Troxler in 1962. We report four deaths associated with 5-IT and a validated 
      high-performance liquid chromatography method for quantitation of the drug. In 
      all four deaths, an autopsy was performed, and femoral venous blood, heart blood, 
      urine and vitreous humor were submitted for toxicological analysis. The blood 
      specimens were subjected to comprehensive testing that included alcohol analysis 
      by headspace gas chromatography (GC-FID), acidic/neutral, basic drug and opiates 
      screening by liquid chromatography-mass spectrometry (LC-MS-MS), and 
      acidic/neutral, basic and acidic drugs screening by HPLC. In Case 1, a 
      25-year-old male, 3,4-methylenedioxymethamphetamine (MDMA; <0.08 mg/L) and 5-IT 
      (preserved femoral blood 1.2 mg/L; unpreserved femoral blood 0.8 mg/L; cardiac 
      blood 1.2 mg/L; vitreous 0.8 mg/L and urine >10 mg/L) were detected, and death 
      was attributed to the toxic effects of 5-IT. In Case 2, a 25-year-old female, 
      3,4-methylenedioxy-N-methylcathinone (methylone, not quantitated), 
      6-(2-aminopropyl)benzofuran (6-APB; femoral blood <0.08 mg/L) and 5-IT (preserved 
      femoral blood 1.0 mg/L; unpreserved femoral blood 0.9 mg/L; cardiac blood 2.6 
      mg/L; vitreous 1.4 mg/L and urine >10 mg/L) were detected, and death was 
      attributed to the toxic 'cocktail effects' of the drugs. In Case 3, a 22-year-old 
      male with a history of epilepsy, 5-IT (0.5 mg/L femoral blood) and 6-APB (0.2 
      mg/L femoral blood) were detected, and death was attributed to the toxic effects 
      of the drugs, with the role of epilepsy being indeterminate. In Case 4, a 
      25-year-old female, 5-IT (0.4 mg/L femoral blood), amphetamine (0.4 mg/L femoral 
      blood), MDMA (1.5 mg/L femoral blood), 4-methyl-N-ethylcathione, 
      3,4-methylenedioxyamphetamine HCl (MDA), benzylpiperazine and 6-APB were 
      detected, and death was attributed to the 'cocktail effect' of the drugs.
FAU - Seetohul, L Nitin
AU  - Seetohul LN
AD  - Centre for Forensic and Legal Medicine, University of Dundee, UK.
FAU - Pounder, Derrick J
AU  - Pounder DJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20130716
PL  - England
TA  - J Anal Toxicol
JT  - Journal of analytical toxicology
JID - 7705085
RN  - 0 (Designer Drugs)
RN  - 0 (Hallucinogens)
RN  - 0 (Illicit Drugs)
RN  - 0 (Indoles)
RN  - 0 (Solutions)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - W98BOE73HH (5-(2-aminopropyl)indole)
SB  - IM
MH  - Alcohol Drinking/metabolism
MH  - Autopsy
MH  - Chromatography, High Pressure Liquid
MH  - Designer Drugs/analysis/*poisoning
MH  - Female
MH  - Forensic Toxicology/methods
MH  - Hallucinogens/analysis
MH  - Humans
MH  - Illicit Drugs
MH  - Indoles/analysis/*poisoning
MH  - Male
MH  - Marijuana Smoking/metabolism
MH  - Migraine Disorders/complications
MH  - N-Methyl-3,4-methylenedioxyamphetamine/analysis
MH  - Reference Standards
MH  - Reproducibility of Results
MH  - Resuscitation
MH  - Solutions
MH  - Young Adult
MH  - von Willebrand Diseases/complications
EDAT- 2013/07/19 06:00
MHDA- 2013/10/25 06:00
CRDT- 2013/07/18 06:00
PHST- 2013/07/18 06:00 [entrez]
PHST- 2013/07/19 06:00 [pubmed]
PHST- 2013/10/25 06:00 [medline]
AID - bkt053 [pii]
AID - 10.1093/jat/bkt053 [doi]
PST - ppublish
SO  - J Anal Toxicol. 2013 Sep;37(7):447-51. doi: 10.1093/jat/bkt053. Epub 2013 Jul 16.