PMID- 23861470
OWN - NLM
STAT- MEDLINE
DCOM- 20140320
LR  - 20211021
IS  - 1523-5866 (Electronic)
IS  - 1522-8517 (Print)
IS  - 1522-8517 (Linking)
VI  - 15
IP  - 9
DP  - 2013 Sep
TI  - Co-polysomy of chromosome 1q and 19p predicts worse prognosis in 1p/19q codeleted 
      oligodendroglial tumors: FISH analysis of 148 consecutive cases.
PG  - 1244-50
LID - 10.1093/neuonc/not092 [doi]
AB  - BACKGROUND: This study aimed to evaluate the prognostic significance of 
      co-polsomy of chromosome 1q and 19p in 1p/19q codeleted oligodendroglial tumors 
      (ODGs). METHODS: In a series of 148 ODGs with 1p/19q deletion, co-polysomy of 1q 
      and 19p was detected by fluorescence in situ hybridization (FISH). Log-rank 
      analysis and Cox regression methods were used to compare Kaplan-Meier plots and 
      identify factors associated with worse prognosis. RESULTS: There were 104 (70.3%) 
      low-grade ODGs and 44 (29.7%) high-grade ODGs. Co-polysomy was independently 
      associated with shorter progression-free survival and overall survival in 1p/19q 
      codeleted ODGs, irrespective of tumor grades. The odds ratio of without and with 
      co-polysomy was 0.263 (95% confidence interval [CI], 0.089-0.771; P = .015) for 
      progression-free survival and 0.213 (95% CI, 0.060-0.756; P = .017) for overall 
      survival. Subgroup analysis confirmed this trend in both low-grade and high-grade 
      ODGs, although the P value for high-grade ODGs was marginally significant. 
      CONCLUSIONS: Co-polysomy of 1q and 19p could be used as a marker to independently 
      predict worse prognoses and guide individual therapy in 1p/19q codeleted ODGs.
FAU - Ren, Xiaohui
AU  - Ren X
AD  - Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 
      100050, China.
FAU - Jiang, Haihui
AU  - Jiang H
FAU - Cui, Xiangli
AU  - Cui X
FAU - Cui, Yong
AU  - Cui Y
FAU - Ma, Jun
AU  - Ma J
FAU - Jiang, Zhongli
AU  - Jiang Z
FAU - Sui, Dali
AU  - Sui D
FAU - Lin, Song
AU  - Lin S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130716
PL  - England
TA  - Neuro Oncol
JT  - Neuro-oncology
JID - 100887420
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers
MH  - Brain Neoplasms/*diagnosis/*genetics
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - Chromosomes, Human, Pair 19/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Oligodendroglioma/*diagnosis/*genetics
MH  - Prognosis
MH  - Young Adult
PMC - PMC3748924
OTO - NOTNLM
OT  - 1p/19q co-deletion
OT  - co-polysomy
OT  - oligodendroglial tumors
OT  - prognosis
OT  - survival
EDAT- 2013/07/19 06:00
MHDA- 2014/03/22 06:00
PMCR- 2014/09/01
CRDT- 2013/07/18 06:00
PHST- 2013/07/18 06:00 [entrez]
PHST- 2013/07/19 06:00 [pubmed]
PHST- 2014/03/22 06:00 [medline]
PHST- 2014/09/01 00:00 [pmc-release]
AID - not092 [pii]
AID - 10.1093/neuonc/not092 [doi]
PST - ppublish
SO  - Neuro Oncol. 2013 Sep;15(9):1244-50. doi: 10.1093/neuonc/not092. Epub 2013 Jul 
      16.