PMID- 23861585
OWN - NLM
STAT- MEDLINE
DCOM- 20140424
LR  - 20211021
IS  - 1178-2013 (Electronic)
IS  - 1176-9114 (Print)
IS  - 1176-9114 (Linking)
VI  - 8
DP  - 2013
TI  - Hyaluronan-cisplatin conjugate nanoparticles embedded in Eudragit S100-coated 
      pectin/alginate microbeads for colon drug delivery.
PG  - 2399-407
LID - 10.2147/IJN.S46613 [doi]
AB  - Hyaluronan-cisplatin conjugate nanoparticles (HCNPs) were chosen as 
      colon-targeting drug-delivery carriers due to the observation that a variety of 
      malignant tumors overexpress hyaluronan receptors. HCNPs were prepared by mixing 
      cisplatin with a hyaluronan solution, followed by dialysis to remove trace 
      elements. The cells treated with HCNPs showed significantly lower viability than 
      those treated with cisplatin alone. HCNPs were entrapped in Eudragit S100-coated 
      pectinate/alginate microbeads (PAMs) by using an electrospray method and a 
      polyelectrolyte multilayer-coating technique in aqueous solution. The release 
      profile of HCNPs from Eudragit S100-coated HCNP-PAMs was pH-dependent. The 
      percentage of 24-hour drug release was approximately 25.1% and 39.7% in pH 1.2 
      and pH 4.5 media, respectively. However, the percentage of drug released quickly 
      rose to 75.6% at pH 7.4. Moreover, the result of an in vivo nephrotoxicity study 
      demonstrated that Eudragit S100-coated HCNP-PAMs treatment could mitigate the 
      nephrotoxicity that resulted from cisplatin. From these results, it can be 
      concluded that Eudragit S100-coated HCNP-PAMs are promising carriers for 
      colon-specific drug delivery.
FAU - Tsai, Shiao-Wen
AU  - Tsai SW
AD  - Graduate Institute of Biochemical and Biomedical Engineering, Chang Gung 
      University, Taoyuan, Taiwan.
FAU - Yu, Ding-Syuan
AU  - Yu DS
FAU - Tsao, Shu-Wei
AU  - Tsao SW
FAU - Hsu, Fu-Yin
AU  - Hsu FY
LA  - eng
PT  - Journal Article
DEP - 20130703
PL  - New Zealand
TA  - Int J Nanomedicine
JT  - International journal of nanomedicine
JID - 101263847
RN  - 0 (Alginates)
RN  - 0 (Hexuronic Acids)
RN  - 0 (Nanoconjugates)
RN  - 0 (Polymethacrylic Acids)
RN  - 25086-15-1 (methylmethacrylate-methacrylic acid copolymer)
RN  - 89NA02M4RX (Pectins)
RN  - 8A5D83Q4RW (Glucuronic Acid)
RN  - 9004-61-9 (Hyaluronic Acid)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Alginates/chemistry/pharmacokinetics
MH  - Animals
MH  - Body Weight/drug effects
MH  - Cell Survival/drug effects
MH  - Cisplatin/*chemistry/pharmacokinetics/pharmacology/toxicity
MH  - Colonic Neoplasms
MH  - Glucuronic Acid/chemistry/pharmacokinetics
MH  - HCT116 Cells
MH  - Hexuronic Acids/chemistry/pharmacokinetics
MH  - Humans
MH  - Hyaluronic Acid/*chemistry/pharmacokinetics/toxicity
MH  - Male
MH  - *Microspheres
MH  - Nanoconjugates/*chemistry/toxicity
MH  - Pectins/chemistry/pharmacokinetics
MH  - Polymethacrylic Acids/*chemistry/pharmacokinetics
MH  - Rats
MH  - Rats, Wistar
PMC - PMC3704403
OTO - NOTNLM
OT  - alginate
OT  - cisplatin
OT  - drug delivery
OT  - hyaluronan
OT  - pH-dependent
OT  - pectin
EDAT- 2013/07/19 06:00
MHDA- 2014/04/25 06:00
PMCR- 2013/07/03
CRDT- 2013/07/18 06:00
PHST- 2013/07/18 06:00 [entrez]
PHST- 2013/07/19 06:00 [pubmed]
PHST- 2014/04/25 06:00 [medline]
PHST- 2013/07/03 00:00 [pmc-release]
AID - ijn-8-2399 [pii]
AID - 10.2147/IJN.S46613 [doi]
PST - ppublish
SO  - Int J Nanomedicine. 2013;8:2399-407. doi: 10.2147/IJN.S46613. Epub 2013 Jul 3.