PMID- 23862111
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130717
LR  - 20211021
IS  - 2228-5806 (Print)
IS  - 2228-5814 (Electronic)
IS  - 2228-5806 (Linking)
VI  - 15
IP  - 2
DP  - 2013 Summer
TI  - Investigation The Role of Gender on The HLA-DRB1 and -DQB1 Association with Type 
      1 Diabetes Mellitus in Iranian Patients.
PG  - 108-15
AB  - OBJECTIVE: Type 1 diabetes mellitus (T1D) is an autoimmune and multifactorial 
      disorder. Subsequent analysis on human leukocyte antigen ( HLA) region shows that 
      HLA-DRB1 and -DQB1 genes have the strongest association with T1D. In this study, 
      for the first time, we investigated the influence of gender on the HLA-DRB1 and 
      -DQB1 association with type 1 diabetes mellitus in Iranian patients in order to 
      determine gender dependent HLA heterogeneity in Iranian T1D patients. MATERIALS 
      AND METHODS: In this case control study, the HLA-DRB1 and -DQB1 typing were 
      performed on 105 Iranian T1D patients and 100 healthy controls. The data were 
      evaluated by using Fisher exact test. RESULTS: Our results indicate that 
      DRB1*04:01, DQB1*03:02 alleles and DRB1*04:01- DQB1*03:02 haplotype were 
      significantly more frequent in male T1D patients than females. Also, DRB1*03:01, 
      DRB1*15:01, DQB1*06:01 alleles, DQB1*03:01/05:01 genotype, DRB1*03:01-DQB1*02:01 
      and DRB1*15:01-DQB1*06:01 haplotypes were significantly higher in female T1D 
      group than males. Furthermore, our results showed that DRB1*04:01 and DQB1*03:02 
      alleles were significantly more frequent in male T1D patients 1-5 years old at 
      onset than females with similar condition. The DRB1*03:01 allele and DRB1*03:01- 
      DQB1*02:01 haplotype were significantly higher in female T1D patients 6-10 years 
      old at onset than males with similar condition. The DRB1*15:01 allele and 
      DRB1*15:01-DQB1*06:01 haplotype were significantly more frequent in female T1D 
      patients 16-20 years old at onset than males with similar condition. CONCLUSION: 
      Our findings suggest that gender has a significant influence on the distribution 
      of HLA-DR and -DQ alleles, genotypes and haplotypes. Also, distribution of the 
      HLA-DRB1 and -DQB1 alleles, genotypes and haplotypes vary based on the gender of 
      T1D patients in different age at onset.
FAU - Sayad, Arezou
AU  - Sayad A
AD  - 1. Department of Neurogenetics, Iranian Centre of Neurological Research, Tehran 
      University of Medical Sciences, Tehran, Iran ; 2. Department of Medical Genetics, 
      Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran.
FAU - Akbari, Mohammad Taghi
AU  - Akbari MT
FAU - Pajouhi, Mohammad
AU  - Pajouhi M
FAU - Mostafavi, Feridoon
AU  - Mostafavi F
FAU - Kazemnejad, Anooshirvan
AU  - Kazemnejad A
FAU - Zamani, Mahdi
AU  - Zamani M
LA  - eng
PT  - Journal Article
DEP - 20130702
PL  - Iran
TA  - Cell J
JT  - Cell journal
JID - 101566618
PMC - PMC3712770
OTO - NOTNLM
OT  - Age at Onset
OT  - Gender
OT  - HLA-DQB1
OT  - HLA-DRB1
OT  - Type 1 Diabetes
EDAT- 2013/07/19 06:00
MHDA- 2013/07/19 06:01
PMCR- 2013/07/01
CRDT- 2013/07/18 06:00
PHST- 2011/11/20 00:00 [received]
PHST- 2012/10/14 00:00 [accepted]
PHST- 2013/07/18 06:00 [entrez]
PHST- 2013/07/19 06:00 [pubmed]
PHST- 2013/07/19 06:01 [medline]
PHST- 2013/07/01 00:00 [pmc-release]
PST - ppublish
SO  - Cell J. 2013 Summer;15(2):108-15. Epub 2013 Jul 2.