PMID- 23863652
OWN - NLM
STAT- MEDLINE
DCOM- 20130820
LR  - 20151119
IS  - 0385-0684 (Print)
IS  - 0385-0684 (Linking)
VI  - 40
IP  - 6
DP  - 2013 Jun
TI  - [Comparison of HER2 immunohistochemical results for advanced gastric cancer 
      obtained on using 3 different antibodies].
PG  - 755-9
AB  - We compared the results of immunohistochemical assessment of HER2 expression in 
      107 samples of advanced gastric cancer on using 3 currently used antibodies. 
      Expression was scored as 0 to 3+, and equivocal or discordant cases were 
      subjected to fluorescence in situ hybridization(FISH)analysis. HER2 scores of 
      2+or 3+were noted in 16.8% of cases(18/ 107)using SV2-61g, in 29.9% of 
      cases(32/107)using Dako HercepTest, and in 34.6% of cases(37/107)using 4B5. The 
      results of the HER2 test differed according to the antibodies used for 
      immunohistochemistry preceding FISH analysis, and the HER2 positive rates after 
      the FISH analysis were 14.0%(15/107)using SV2-61g, 19.6% (21/107)using Dako 
      HercepTest, and 22.4% (24/107)using 4B5. Thus, therapeutic decisions might be 
      considerably influenced by the antibody used for the HER2 test.
FAU - Abe, Mitsunobu
AU  - Abe M
AD  - Dept. of Pathology and Laboratory Medicine, Yamagata Prefectural Central 
      Hospital, Japan.
FAU - Tsuchiya, Kohki
AU  - Tsuchiya K
FAU - Yanagawa, Naoki
AU  - Yanagawa N
FAU - Ogata, Shin-ya
AU  - Ogata SY
FAU - Nomura, Takashi
AU  - Nomura T
FAU - Fukushima, Norimasa
AU  - Fukushima N
FAU - Tamura, Gen
AU  - Tamura G
LA  - jpn
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Gan To Kagaku Ryoho
JT  - Gan to kagaku ryoho. Cancer & chemotherapy
JID - 7810034
RN  - 0 (Antibodies)
RN  - EC 2.7.10.1 (ERBB2 protein, human)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - *Antibodies
MH  - Humans
MH  - Immunohistochemistry/*methods
MH  - Receptor, ErbB-2/*analysis/immunology
MH  - Stomach Neoplasms/*chemistry/pathology
EDAT- 2013/07/19 06:00
MHDA- 2013/08/21 06:00
CRDT- 2013/07/19 06:00
PHST- 2013/07/19 06:00 [entrez]
PHST- 2013/07/19 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
PST - ppublish
SO  - Gan To Kagaku Ryoho. 2013 Jun;40(6):755-9.