PMID- 23866082
OWN - NLM
STAT- MEDLINE
DCOM- 20150406
LR  - 20140117
IS  - 1440-0960 (Electronic)
IS  - 0004-8380 (Linking)
VI  - 55
IP  - 1
DP  - 2014 Feb
TI  - Drug-reaction eosinophilia and systemic symptoms and drug-induced 
      hypersensitivity syndrome.
PG  - 15-23
LID - 10.1111/ajd.12085 [doi]
AB  - Drug reaction with eosinophilia and systemic symptoms (DRESS), also known as 
      drug-induced hypersensitivity syndrome (DIHS), is a rare, severe cutaneous 
      adverse reaction characterised by fever, rash, lymphadenopathy, eosinophilia 
      and/or other leukocyte abnormalities, and internal organ involvement and often 
      has a relapsing-remitting course despite withdrawal of the drug. The drugs that 
      are most implicated include aromatic anticonvulsants, allopurinol, sulphonamides, 
      antiretrovirals (abacavir and nevirapine), and minocycline. The pathogenesis of 
      DRESS/DIHS is far from clear but probably involves a combination of impaired 
      pharmacokinetics and the accumulation of drug metabolites, the sequential 
      reactivation of the herpesvirus family and genetic susceptibility conferred by 
      the association with certain human leukocyte antigen (HLA) class I alleles. The 
      strong association between abacavir and HLA-B*5701 has enabled pharmacogenetics 
      screening to be employed successfully to minimise the occurrence of 
      hypersensitivity. A prolonged course of oral corticosteroids is required to treat 
      DRESS/DIHS, given the relapsing-remitting nature of the condition with i.v. 
      immunoglobulin and valgangciclovir reserved for refractory or life-threatening 
      cases.
CI  - (c) 2013 The Australasian College of Dermatologists.
FAU - Fernando, Suran L
AU  - Fernando SL
AD  - Department of Clinical Immunology and Allergy, Royal North Shore Hospital, 
      Sydney, Australia; PaLMS Immunorheumatology Laboratory, Sydney, Australia; Sydney 
      Medical School-Northern, Sydney University, Sydney, Australia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130719
PL  - Australia
TA  - Australas J Dermatol
JT  - The Australasian journal of dermatology
JID - 0135232
RN  - 0 (Anti-Retroviral Agents)
RN  - 0 (Anticonvulsants)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Sulfonamides)
RN  - 63CZ7GJN5I (Allopurinol)
RN  - FYY3R43WGO (Minocycline)
SB  - IM
MH  - Allopurinol/adverse effects
MH  - Anti-Retroviral Agents/adverse effects
MH  - Anticonvulsants/adverse effects
MH  - Drug Hypersensitivity Syndrome/*diagnosis/*etiology/genetics/therapy
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Minocycline/adverse effects
MH  - Sulfonamides/adverse effects
OTO - NOTNLM
OT  - DIHS
OT  - DRESS
OT  - abacavir hypersensitivity
OT  - anticonvulsant hypersensitivity syndrome
OT  - drug allergy
OT  - drug hypersensitivity
OT  - drug-induced hypersensitivity syndrome
OT  - drug-reaction eosinophilia and systemic symptoms
OT  - pharmacogenetics
OT  - severe cutaneous adverse reaction
EDAT- 2013/07/20 06:00
MHDA- 2015/04/07 06:00
CRDT- 2013/07/20 06:00
PHST- 2013/04/30 00:00 [received]
PHST- 2013/05/05 00:00 [accepted]
PHST- 2013/07/20 06:00 [entrez]
PHST- 2013/07/20 06:00 [pubmed]
PHST- 2015/04/07 06:00 [medline]
AID - 10.1111/ajd.12085 [doi]
PST - ppublish
SO  - Australas J Dermatol. 2014 Feb;55(1):15-23. doi: 10.1111/ajd.12085. Epub 2013 Jul 
      19.