PMID- 23866879
OWN - NLM
STAT- MEDLINE
DCOM- 20130930
LR  - 20220409
IS  - 1097-6787 (Electronic)
IS  - 0190-9622 (Linking)
VI  - 69
IP  - 2
DP  - 2013 Aug
TI  - Toxic epidermal necrolysis: Part II. Prognosis, sequelae, diagnosis, differential 
      diagnosis, prevention, and treatment.
PG  - 187.e1-16; quiz 203-4
LID - S0190-9622(13)00509-4 [pii]
LID - 10.1016/j.jaad.2013.05.002 [doi]
AB  - Toxic epidermal necrolysis (TEN) is a life-threatening, typically drug-induced, 
      mucocutaneous disease. TEN has a high mortality rate, making early diagnosis and 
      treatment of paramount importance. New but experimental diagnostic tools that 
      measure serum granulysin and high-mobility group protein B1 (HMGB1) offer the 
      potential to differentiate early TEN from other, less serious drug reactions, but 
      these tests have not been validated and are not readily available. The mainstay 
      of treatment for TEN involves discontinuation of the offending drug, specialized 
      care in an intensive care unit or burn center, and supportive therapy. 
      Pharmacogenetic studies have clearly established a link between human leukocyte 
      antigen allotype and TEN. Human leukocyte antigen testing should be performed on 
      patients of East Asian descent before the initiation of carbamezapine and on all 
      patients before the initiation of abacavir. The effectiveness of systemic 
      steroids, intravenous immunoglobulins, plasmapheresis, cyclosporine, biologics, 
      and other agents is uncertain.
CI  - Copyright (c) 2013 American Academy of Dermatology, Inc. Published by Mosby, Inc. 
      All rights reserved.
FAU - Schwartz, Robert A
AU  - Schwartz RA
AD  - Dermatology, Preventive Medicine, and Pathology, Rutgers University New Jersey 
      Medical School, Newark, New Jersey 07103-2714, USA. roschwar@cal.berkeley.edu
FAU - McDonough, Patrick H
AU  - McDonough PH
FAU - Lee, Brian W
AU  - Lee BW
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
SB  - IM
CIN - J Am Acad Dermatol. 2014 Jul;71(1):195-6. PMID: 24947692
MH  - Acute Generalized Exanthematous Pustulosis/diagnosis/mortality/therapy
MH  - Biopsy, Needle
MH  - Diagnosis, Differential
MH  - Disease Progression
MH  - Early Diagnosis
MH  - Education, Medical, Continuing
MH  - Erythema Multiforme/diagnosis/mortality/therapy
MH  - Female
MH  - Graft vs Host Disease/diagnosis/mortality/therapy
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Primary Prevention/methods
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Staphylococcal Skin Infections/diagnosis/mortality/therapy
MH  - Stevens-Johnson Syndrome/*diagnosis/mortality/prevention & control/*therapy
MH  - Survival Analysis
OTO - NOTNLM
OT  - ALDEN
OT  - BSA
OT  - EM
OT  - EMM
OT  - EMm
OT  - Fas ligand
OT  - FasL
OT  - GCSF
OT  - HLA
OT  - HMGB1
OT  - IVIG
OT  - LTT
OT  - N-acetylcysteine
OT  - NAC
OT  - SCORTEN
OT  - SJS
OT  - SSSS
OT  - Stevens-Johnson syndrome
OT  - TEN
OT  - TNF
OT  - algorithm for drug causality for epidermal necrolysis
OT  - biologics
OT  - body surface area
OT  - cyclosporine
OT  - drug eruption
OT  - erythema multiforme
OT  - erythema multiforme major
OT  - erythema multiforme minor
OT  - granulocyte colony-stimulating factor
OT  - granulysin
OT  - high-mobility group protein B1
OT  - human leukocyte antigen
OT  - intravenous immunoglobulin
OT  - lymphocyte transformation testing
OT  - penicillin
OT  - plasmapheresis
OT  - severity of illness score for toxic epidermal necrolysis
OT  - staphylococcal scalded skin syndrome
OT  - systemic steroids
OT  - toxic epidermal necrolysis
OT  - tumor necrosis factor
EDAT- 2013/07/23 06:00
MHDA- 2013/10/01 06:00
CRDT- 2013/07/23 06:00
PHST- 2013/04/11 00:00 [received]
PHST- 2013/05/06 00:00 [revised]
PHST- 2013/05/10 00:00 [accepted]
PHST- 2013/07/23 06:00 [entrez]
PHST- 2013/07/23 06:00 [pubmed]
PHST- 2013/10/01 06:00 [medline]
AID - S0190-9622(13)00509-4 [pii]
AID - 10.1016/j.jaad.2013.05.002 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 2013 Aug;69(2):187.e1-16; quiz 203-4. doi: 
      10.1016/j.jaad.2013.05.002.