PMID- 23867975
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160126
LR  - 20220310
IS  - 2157-3999 (Electronic)
IS  - 2157-3999 (Linking)
VI  - 5
DP  - 2013 Jul 8
TI  - The 6-Minute Walk Test and Person-Reported Outcomes in Boys with Duchenne 
      Muscular Dystrophy and Typically Developing Controls: Longitudinal Comparisons 
      and Clinically-Meaningful Changes Over One Year.
LID - ecurrents.md.9e17658b007eb79fcd6f723089f79e06 [pii]
LID - 10.1371/currents.md.9e17658b007eb79fcd6f723089f79e06 [doi]
AB  - INTRODUCTION: Data is currently lacking anchoring a 30-meter longitudinal change 
      in walking ability by 6-minute walk test (6MWT) in Duchenne muscular dystrophy as 
      a minimal clinically important difference and "clinically meaningful" 
      person-reported outcomes (PROs) at differing levels of ambulatory ability. 
      METHODS: We describe correlation between measures, 1-year change in measures, and 
      correlation of 1-year changes between measures for the six-minute walk test 
      (6MWT), 10-meter run/walk velocity, PedsQL and POSNA Pediatric Outcomes Data 
      Collection Instrument (PODCI) in 24 4-12 year old. ambulatory DMD and 36 typical 
      controls, and determine if minimal clinically important differences (MCID) of 
      PROs contribute to different estimates of 6-minute walk distance (6MWD) change at 
      differing levels of ability. RESULTS: PedsQL total and physical function and 
      PODCI global, transfer/mobility and sports/physical function PROs demonstrated 
      significant differences between DMD and controls (p<0.00001). In DMD, 6MWD and 
      10-meter run/walk velocity were correlated with PODCI domain scores, with the 
      transfer/mobility scale showing the strongest relationship (r=0.79 and r=0.76). 
      In DMD, 6MWD distance and 10-meter run/walk velocity weakly correlated with 
      PedsQL domain scores. In DMD, 6MWD, 10-meter run/walk velocity, and PODCI global 
      and transfer and basic mobility demonstrated significant one-year change and 
      exceeded the amount of change representing MCID. In DMD, 6MWD change highly 
      correlated with change in PODCI global and PODCI transfer/mobility scores (r=0.76 
      and r=0.93). PODCI global and PODCI transfer/mobility scales provided the best 
      estimates of 6MWT performance. A "meaningful" 4.5 point change in a low PODCI 
      transfer / basic mobility score of 30 to 34.5 was associated with a 5.6m 6MWD 
      change from 150.3 to 155.9m. At PODCI levels closer to normative levels for 
      healthy controls, the change in 6MWD distance associated with a "meaningful" 
      change in PODCI scores was almost 46m. DISCUSSION: At lower levels of function, 
      smaller increases in 6MWD result in meaningful change in quality of life (QoL) 
      instrument scores. At higher levels of function, larger increases may be 
      necessary to achieve the same QoL change score.
FAU - Henricson, Erik
AU  - Henricson E
AD  - Department of Physical Medicine and Rehabilitation, University of California, 
      Davis, Sacramento, California, USA.
FAU - Abresch, Richard
AU  - Abresch R
AD  - Department of Physical Medicine and Rehabilitation, University of California, 
      Davis, Sacramento, California, USA.
FAU - Han, Jay J
AU  - Han JJ
AD  - Department of Physical Medicine and Rehabilitation, University of California, 
      Davis, Sacramento, California, USA.
FAU - Nicorici, Alina
AU  - Nicorici A
AD  - Department of Physical Medicine and Rehabilitation, University of California, 
      Davis, Sacramento, California, USA.
FAU - Goude Keller, Erica
AU  - Goude Keller E
AD  - Department of Physical Medicine and Rehabilitation, University of California, 
      Davis, Sacramento, California, USA.
FAU - de Bie, Evan
AU  - de Bie E
AD  - Department of Physical Medicine and Rehabilitation, University of California, 
      Davis, Sacramento, California, USA.
FAU - McDonald, Craig M
AU  - McDonald CM
AD  - Department of Physical Medicine and Rehabilitation, University of California, 
      Davis, Sacramento, California, USA.
LA  - eng
GR  - R01 AR061875/AR/NIAMS NIH HHS/United States
GR  - R01 AR062380/AR/NIAMS NIH HHS/United States
PT  - Journal Article
DEP - 20130708
PL  - United States
TA  - PLoS Curr
JT  - PLoS currents
JID - 101515638
PMC - PMC3712467
EDAT- 2013/07/23 06:00
MHDA- 2013/07/23 06:01
PMCR- 2015/11/18
CRDT- 2016/01/27 06:00
PHST- 2016/01/27 06:00 [entrez]
PHST- 2013/07/23 06:00 [pubmed]
PHST- 2013/07/23 06:01 [medline]
PHST- 2015/11/18 00:00 [pmc-release]
AID - ecurrents.md.9e17658b007eb79fcd6f723089f79e06 [pii]
AID - 10.1371/currents.md.9e17658b007eb79fcd6f723089f79e06 [doi]
PST - epublish
SO  - PLoS Curr. 2013 Jul 8;5:ecurrents.md.9e17658b007eb79fcd6f723089f79e06. doi: 
      10.1371/currents.md.9e17658b007eb79fcd6f723089f79e06.