PMID- 23868462
OWN - NLM
STAT- Publisher
LR  - 20240227
IS  - 1520-7560 (Electronic)
IS  - 1520-7552 (Linking)
DP  - 2013 Jul 18
TI  - Type 2 Diabetes Mellitus and Alzheimer's Disease: from physiopathology to 
      treatment implications.
LID - 10.1002/dmrr.2442 [doi]
AB  - Alzheimer's Disease (AD) is the most common cause of dementia worldwide. Type 2 
      Diabetes Mellitus (T2DM) is a disease characterized by insulin resistance (IR) 
      and progressive beta cell failure, and affected individuals are at increased risk to 
      develop several forms of cognitive dysfunction, including AD. Different 
      mechanisms have already been identified linking visceral obesity, IR and AD. 
      Insulin resistance is associated with a decrease in glucose uptake by neurons, an 
      increase in Amyloid beta production and secretion, in the formation of senile 
      plaques, and also in tau protein phosphorylation. Other mechanisms also include a 
      decrease in Insulin Degrading Enzyme (IDE) activity and an increase in oxidative 
      stress secondary to hyperglycemia. Taken together, these mechanisms suggest that 
      drugs used to ameliorate hyperglycemia and IR may also have beneficial effects in 
      diabetic patients with AD. Indeed, manuscripts investigating the effects of 
      metformin, thiazolinediones, leptin, GLP-1 therapies, insulin and bariatric 
      surgery in cognition and AD have been published with very promising results, and 
      may indicate an alternative approach for these patients. This article is 
      protected by copyright. All rights reserved.
CI  - This article is protected by copyright. All rights reserved.
FAU - Moreira, Rodrigo O
AU  - Moreira RO
AD  - Instituto Estadual de Diabetes e Endocrinologia (IEDE) e Pontificia Universidade 
      Catolica do Rio de Janeiro (PUC-RJ), Rio de Janeiro, Brasil.
FAU - Campos, Stella C
AU  - Campos SC
FAU - Soldera, Ana L
AU  - Soldera AL
LA  - eng
PT  - Journal Article
DEP - 20130718
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
OTO - NOTNLM
OT  - Alzheimer's Disease
OT  - Cognition
OT  - Diabetes Mellitus
EDAT- 2013/07/23 06:00
MHDA- 2013/07/23 06:00
CRDT- 2013/07/23 06:00
PHST- 2012/08/06 00:00 [received]
PHST- 2013/02/14 00:00 [revised]
PHST- 2013/06/03 00:00 [accepted]
PHST- 2013/07/23 06:00 [entrez]
PHST- 2013/07/23 06:00 [pubmed]
PHST- 2013/07/23 06:00 [medline]
AID - 10.1002/dmrr.2442 [doi]
PST - aheadofprint
SO  - Diabetes Metab Res Rev. 2013 Jul 18. doi: 10.1002/dmrr.2442.