PMID- 23869328
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130722
LR  - 20211021
IS  - 2234-0645 (Print)
IS  - 2234-0653 (Electronic)
IS  - 2234-0645 (Linking)
VI  - 37
IP  - 3
DP  - 2013 Jun
TI  - Effect of the presence of brain-derived neurotrophic factor val(66)met 
      polymorphism on the recovery in patients with acute subcortical stroke.
PG  - 311-9
LID - 10.5535/arm.2013.37.3.311 [doi]
AB  - OBJECTIVE: To investigate the effect of brain-derived neurotrophic factor (BDNF) 
      Val(66)Met polymorphism on the recovery after subcortical stroke, using the 
      modified Rankin Scale (mRS). METHODS: Subcortical stroke patients with copies of 
      BDNF Val(66)Met polymorphism (n=7) were compared to their controls (n=7) without 
      a copy of BDNF Val(66)Met polymorphism after matching for initial severity, 
      location and type of stroke. The mRS scores at 1 and 3 months after discharge 
      from the neurorehabilitation unit were compared between the groups. RESULTS: A 
      repeated measures ANOVA for mRS revealed significant interaction between time and 
      group (F(2, 24) =37.2, p<0.001) and a significant effect of time (F(2, 24)=10.8, 
      p<0.001), thereby reflecting significant differences between the Met allele (+) 
      group and the Met allele (-) group. There was a significant difference in mRS 
      scores at 3 months post-discharge between the two groups (p=0.01) although no 
      difference was evident in mRS scores at 1 month post-discharge between the two 
      groups. There were significant improvements between mRS scores on admission and 
      mRS scores at 1 month post-discharge (p=0.02), and between mRS scores at 1 month 
      post-discharge and mRS scores at 3 months post-discharge (p=0.004) in the Met 
      allele (-) group. CONCLUSION: BDNF Val(66)Met polymorphism may be associated with 
      worse functional outcome in Korean patients with subcortical stroke. Therefore, 
      BDNF Val(66)Met polymorphism should be considered as an important prognostic 
      factor for recovery and responses to rehabilitation therapies after stroke in 
      Korean patients. There is a need for developing different rehabilitation 
      strategies for the population with BDNF Val(66)Met polymorphism. Further studies 
      assessing different outcomes for various functional domains of stroke recovery 
      are needed to clarify the role of BDNF Val(66)Met polymorphism.
FAU - Kim, Won-Seok
AU  - Kim WS
AD  - Department of Rehabilitation Medicine, Seoul National University Bundang 
      Hospital, Seoul National University College of Medicine, Seongnam, Korea.
FAU - Lim, Jong Youb
AU  - Lim JY
FAU - Shin, Joon Ho
AU  - Shin JH
FAU - Park, Hye Kyung
AU  - Park HK
FAU - Tan, Samuel Arnado
AU  - Tan SA
FAU - Park, Kyoung Un
AU  - Park KU
FAU - Paik, Nam-Jong
AU  - Paik NJ
LA  - eng
PT  - Journal Article
DEP - 20130630
PL  - Korea (South)
TA  - Ann Rehabil Med
JT  - Annals of rehabilitation medicine
JID - 101573065
PMC - PMC3713287
OTO - NOTNLM
OT  - Brain plasticity
OT  - Brain-derived neurotrophic factor
OT  - Polymorphism
OT  - Recovery
OT  - Stroke
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2013/07/23 06:00
MHDA- 2013/07/23 06:01
PMCR- 2013/06/01
CRDT- 2013/07/23 06:00
PHST- 2012/11/01 00:00 [received]
PHST- 2012/12/24 00:00 [accepted]
PHST- 2013/07/23 06:00 [entrez]
PHST- 2013/07/23 06:00 [pubmed]
PHST- 2013/07/23 06:01 [medline]
PHST- 2013/06/01 00:00 [pmc-release]
AID - 10.5535/arm.2013.37.3.311 [doi]
PST - ppublish
SO  - Ann Rehabil Med. 2013 Jun;37(3):311-9. doi: 10.5535/arm.2013.37.3.311. Epub 2013 
      Jun 30.