PMID- 23869550
OWN - NLM
STAT- MEDLINE
DCOM- 20131126
LR  - 20130913
IS  - 1365-2141 (Electronic)
IS  - 0007-1048 (Linking)
VI  - 163
IP  - 1
DP  - 2013 Oct
TI  - Biallelic losses of 13q do not confer a poorer outcome in chronic lymphocytic 
      leukaemia: analysis of 627 patients with isolated 13q deletion.
PG  - 47-54
LID - 10.1111/bjh.12479 [doi]
AB  - Losses in 13q as a sole abnormality confer a good prognosis in chronic 
      lymphocytic leukaemia (CLL). Nevertheless, its heterogeneity has been 
      demonstrated and the clinical significance of biallelic 13q deletions remains 
      controversial. We compared the clinico-biological characteristics of a series of 
      627 patients harbouring isolated 13q deletions by fluorescence in situ 
      hybridization (FISH), either monoallelic (13q x 1), biallelic (13q x 2), or the 
      coexistence of both clones (13qM). The most frequent 13q deletion was 13q x 1 
      (82.1%), while 13q x 2 and 13qM represented 8.6% and 9.3% of patients 
      respectively. The median percentage of altered nuclei significantly differed 
      across groups: 55%, 72.5% and 80% in 13q x 1, 13q x 2 and 13qM (P < 0.001). 
      However, no significant differences in the clinical outcome among 13q groups were 
      found. From 84 patients with sequential FISH studies, eight patients lost the 
      remaining allele of 13q whereas none of them changed from 13q x 2 to the 13q x 1 
      group. The percentage of abnormal cells detected by FISH had a significant impact 
      on the five-year cumulative incidence of treatment and the overall survival, 90% 
      being the highest predictive power cut-off. In conclusion, loss of the remaining 
      13q allele is not enough to entail a worse prognosis in CLL. The presence of 
      isolated 13q deletion can be risk-stratified according to the percentage of 
      altered cells.
CI  - (c) 2013 John Wiley & Sons Ltd.
FAU - Puiggros, Anna
AU  - Puiggros A
AD  - Laboratori de Citogenetica Molecular, Laboratori de Citologia Hematologica, 
      Servei de Patologia, Hospital del Mar, Barcelona, Spain; Grup de Recerca 
      Translacional en Neoplasies Hematologiques, Cancer Research Program, 
      IMIM-Hospital del Mar., Barcelona, Spain.
FAU - Delgado, Julio
AU  - Delgado J
FAU - Rodriguez-Vicente, Ana
AU  - Rodriguez-Vicente A
FAU - Collado, Rosa
AU  - Collado R
FAU - Aventin, Anna
AU  - Aventin A
FAU - Luno, Elisa
AU  - Luno E
FAU - Grau, Javier
AU  - Grau J
FAU - Hernandez, Jose Angel
AU  - Hernandez JA
FAU - Marugan, Isabel
AU  - Marugan I
FAU - Ardanaz, Maite
AU  - Ardanaz M
FAU - Gonzalez, Teresa
AU  - Gonzalez T
FAU - Valiente, Alberto
AU  - Valiente A
FAU - Osma, Mar
AU  - Osma M
FAU - Calasanz, Maria Jose
AU  - Calasanz MJ
FAU - Sanzo, Carmen
AU  - Sanzo C
FAU - Carrio, Ana
AU  - Carrio A
FAU - Ortega, Margarita
AU  - Ortega M
FAU - Santacruz, Rodrigo
AU  - Santacruz R
FAU - Abrisqueta, Pau
AU  - Abrisqueta P
FAU - Abella, Eugenia
AU  - Abella E
FAU - Bosch, Francesc
AU  - Bosch F
FAU - Carbonell, Felix
AU  - Carbonell F
FAU - Sole, Francesc
AU  - Sole F
FAU - Hernandez, Jesus Maria
AU  - Hernandez JM
FAU - Espinet, Blanca
AU  - Espinet B
CN  - Grupo Cooperativo Espanol de Citogenetica Hematologica (GCECGH) and Grupo Espanol 
      de Leucemia Linfatica Cronica (GELLC)
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130719
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Alleles
MH  - Chromosome Banding
MH  - *Chromosome Deletion
MH  - *Chromosomes, Human, Pair 13
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics/*mortality/therapy
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - 13q deletion
OT  - biallelic
OT  - chronic lymphocytic leukaemia
OT  - monoallelic
OT  - prognosis
EDAT- 2013/07/23 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/07/23 06:00
PHST- 2013/04/10 00:00 [received]
PHST- 2013/06/12 00:00 [accepted]
PHST- 2013/07/23 06:00 [entrez]
PHST- 2013/07/23 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - 10.1111/bjh.12479 [doi]
PST - ppublish
SO  - Br J Haematol. 2013 Oct;163(1):47-54. doi: 10.1111/bjh.12479. Epub 2013 Jul 19.