PMID- 23869664 OWN - NLM STAT- MEDLINE DCOM- 20140307 LR - 20211021 IS - 1468-1293 (Electronic) IS - 1464-2662 (Print) IS - 1464-2662 (Linking) VI - 14 IP - 10 DP - 2013 Nov TI - Temporal changes and regional differences in treatment uptake of hepatitis C therapy in EuroSIDA. PG - 614-23 LID - 10.1111/hiv.12068 [doi] AB - OBJECTIVES: All HIV/hepatitis C virus (HCV)-coinfected patients with chronic HCV infection and >/= F2 fibrosis should be considered for HCV therapy. This study aimed to determine the rate of HCV treatment uptake among coinfected patients in Europe. METHODS: EuroSIDA patients with viraemic HCV infection were included in the study. Poisson regression was used to identify temporal changes and regional differences in HCV treatment uptake. RESULTS: A total of 1984 patients were included in the study, with a median follow-up time of 168 months [interquartile range (IQR) 121-204 months]. To date, 501 (25.3%) HIV/HCV-coinfected patients have received HCV therapy. Treatment incidence rose from 0.33 [95% confidence interval (CI) 0.16-0.50] per 100 person-years of follow-up (PYFU) in 1998 to 5.93 (95% CI 4.49-7.38) in 2007, falling to 3.78 (95% CI 2.50-5.07) in 2009. After adjustment, CD4 cell count > 350 cells/muL [incidence rate ratio (IRR) 1.33 (95% CI 1.06-1.67) vs. CD4 count 200-350 cells/muL] and >/=F2 liver fibrosis [IRR 1.60 (95% CI 1.14-2.25; P = 0.0065) vs. < F2 fibrosis] were predictors of anti-HCV treatment initiation. However, 22% of patients who remain untreated for HCV, with fibrosis data available, had >/=F2 fibrosis and should have been considered for treatment, while only 36% of treated patients had >/=F2 fibrosis. CONCLUSIONS: Although treatment incidence for HCV has increased, there remain a large proportion of patients indicated for treatment who have yet to be treated. CI - (c) 2013 British HIV Association. FAU - Grint, D AU - Grint D AD - University College London, London, UK. FAU - Peters, L AU - Peters L FAU - Schwarze-Zander, C AU - Schwarze-Zander C FAU - Beniowski, M AU - Beniowski M FAU - Pradier, C AU - Pradier C FAU - Battegay, M AU - Battegay M FAU - Jevtovic, D AU - Jevtovic D FAU - Soriano, V AU - Soriano V FAU - Lundgren, J D AU - Lundgren JD FAU - Rockstroh, J K AU - Rockstroh JK FAU - Kirk, O AU - Kirk O FAU - Mocroft, A AU - Mocroft A CN - EuroSIDA in EuroCoord LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20130719 PL - England TA - HIV Med JT - HIV medicine JID - 100897392 RN - 0 (Antiviral Agents) RN - 0 (Interferon-alpha) RN - 49717AWG6K (Ribavirin) SB - IM MH - Adult MH - Antiviral Agents/*therapeutic use MH - CD4 Lymphocyte Count/statistics & numerical data MH - Cohort Studies MH - Coinfection MH - Drug Therapy, Combination MH - Europe/epidemiology MH - Female MH - HIV Infections/complications/*drug therapy/virology MH - Hepatitis C, Chronic/complications/*drug therapy/virology MH - Humans MH - Interferon-alpha/therapeutic use MH - Liver Cirrhosis/*drug therapy/etiology MH - Male MH - Middle Aged MH - Patient Acceptance of Health Care/psychology/*statistics & numerical data MH - Poisson Distribution MH - Prospective Studies MH - Ribavirin/therapeutic use PMC - PMC4030620 OTO - NOTNLM OT - EuroSIDA OT - HIV/HCV coinfection OT - PEG-interferon OT - ribavirin OT - treatment completion FIR - Losso, M IR - Losso M FIR - Kundro, M IR - Kundro M FIR - Ramos, J M IR - Ramos JM FIR - Vetter, N IR - Vetter N FIR - Zangerle, R IR - Zangerle R FIR - Karpov, I IR - Karpov I FIR - Vassilenko, A IR - Vassilenko A FIR - Mitsura, V M IR - Mitsura VM FIR - Suetnov, O IR - Suetnov O FIR - Clumeck, N IR - Clumeck N FIR - De Wit, S IR - De Wit S FIR - Delforge, M IR - Delforge M FIR - Florence, E IR - Florence E FIR - Vandekerckhove, L IR - Vandekerckhove L FIR - Hadziosmanovic, V IR - Hadziosmanovic V FIR - Kostov, K IR - Kostov K FIR - Begovac, J IR - Begovac J FIR - Machala, L IR - Machala L FIR - Jilich, D IR - Jilich D FIR - Sedlacek, D IR - Sedlacek D FIR - Nielsen, J IR - Nielsen J FIR - Kronborg, G IR - Kronborg G FIR - Benfield, T IR - Benfield T FIR - Larsen, M IR - Larsen M FIR - Gerstoft, J IR - Gerstoft J FIR - Katzenstein, T IR - Katzenstein T FIR - Hansen, A B E IR - Hansen AB FIR - Skinhoj, P IR - Skinhoj P FIR - Pedersen, C IR - Pedersen C FIR - Ostergaard, L IR - Ostergaard L FIR - Dragsted, U B IR - Dragsted U FIR - Nielsen, L N IR - Nielsen L FIR - Zilmer, K IR - Zilmer K FIR - Smidt, J IR - Smidt J FIR - Ristola, M IR - Ristola M FIR - Katlama, C IR - Katlama C FIR - Viard, J-P IR - Viard JP FIR - Girard, P-M IR - Girard PM FIR - Vanhems, P IR - Vanhems P FIR - Pradier, C IR - Pradier C FIR - Dabis, F IR - Dabis F FIR - Neau, D IR - Neau D FIR - Duvivier, C IR - Duvivier C FIR - Rockstroh, J IR - Rockstroh J FIR - Schmidt, R IR - Schmidt R FIR - van Lunzen, J IR - van Lunzen J FIR - Degen, O IR - Degen O FIR - Stellbrink, H J IR - Stellbrink HJ FIR - Bickel, M IR - Bickel M FIR - Goethe, J W IR - Goethe JW FIR - Bogner, J IR - Bogner J FIR - Fatkenheuer, G IR - Fatkenheuer G FIR - Kosmidis, J IR - Kosmidis J FIR - Gargalianos, P IR - Gargalianos P FIR - Xylomenos, G IR - Xylomenos G FIR - Perdios, J IR - Perdios J FIR - Sambatakou, H IR - Sambatakou H FIR - Banhegyi, D IR - Banhegyi D FIR - Gottfredsson, M IR - Gottfredsson M FIR - Mulcahy, F IR - Mulcahy F FIR - Yust, I IR - Yust I FIR - Turner, D IR - Turner D FIR - Burke, M IR - Burke M FIR - Pollack, S IR - Pollack S FIR - Hassoun, G IR - Hassoun G FIR - Maayan, S IR - Maayan S FIR - D'Arminio Monforte, A IR - D'Arminio Monforte A FIR - Esposito, R IR - Esposito R FIR - Mazeu, I IR - Mazeu I FIR - Mussini, C IR - Mussini C FIR - Arici, C IR - Arici C FIR - Pristera, R IR - Pristera R FIR - Mazzotta, F IR - Mazzotta F FIR - Gabbuti, A IR - Gabbuti A FIR - Annunziata, S Maria IR - Annunziata SM FIR - Vullo, V IR - Vullo V FIR - Lichtner, M IR - Lichtner M FIR - Chirianni, A IR - Chirianni A FIR - Montesarchio, E IR - Montesarchio E FIR - Gargiulo, M IR - Gargiulo M FIR - Antonucci, G IR - Antonucci G FIR - Testa, A IR - Testa A FIR - D'Offizi, G IR - D'Offizi G FIR - Vlassi, C IR - Vlassi C FIR - Zaccarelli, M IR - Zaccarelli M FIR - Antorini, A IR - Antorini A FIR - Lazzarin, A IR - Lazzarin A FIR - Castagna, A IR - Castagna A FIR - Gianotti, N IR - Gianotti N FIR - Galli, M IR - Galli M FIR - Ridolfo, A IR - Ridolfo A FIR - Sacco, L IR - Sacco L FIR - Rozentale, B IR - Rozentale B FIR - Zeltina, I IR - Zeltina I FIR - Chaplinskas, S IR - Chaplinskas S FIR - Staub, T IR - Staub T FIR - Hemmer, R IR - Hemmer R FIR - Reiss, P IR - Reiss P FIR - Ormaasen, V IR - Ormaasen V FIR - Maeland, A IR - Maeland A FIR - Bruun, J IR - Bruun J FIR - Knysz, B IR - Knysz B FIR - Gasiorowski, J IR - Gasiorowski J FIR - Horban, A IR - Horban A FIR - Bakowska, E IR - Bakowska E FIR - Grzeszczuk, A IR - Grzeszczuk A FIR - Flisiak, R IR - Flisiak R FIR - Boron-Kaczmarska, A IR - Boron-Kaczmarska A FIR - Pynka, M IR - Pynka M FIR - Parczewski, M IR - Parczewski M FIR - Beniowski, M IR - Beniowski M FIR - Mularska, E IR - Mularska E FIR - Trocha, H IR - Trocha H FIR - Jablonowska, E IR - Jablonowska E FIR - Malolepsza, E IR - Malolepsza E FIR - Wojcik, K IR - Wojcik K FIR - Antunes, F IR - Antunes F FIR - Doroana, M IR - Doroana M FIR - Caldeira, L IR - Caldeira L FIR - Mansinho, K IR - Mansinho K FIR - Maltez, F IR - Maltez F FIR - Duiculescu, D IR - Duiculescu D FIR - Babes, Victor IR - Babes V FIR - Rakhmanova, A IR - Rakhmanova A FIR - Rakhmanova, A IR - Rakhmanova A FIR - Buzunova, S IR - Buzunova S FIR - Khromova, I IR - Khromova I FIR - Kuzovatova, E IR - Kuzovatova E FIR - Jevtovic, D IR - Jevtovic D FIR - Mokras, M IR - Mokras M FIR - Stanekova, D IR - Stanekova D FIR - Tomazic, J IR - Tomazic J FIR - Gonzalez-Lahoz, J IR - Gonzalez-Lahoz J FIR - Soriano, V IR - Soriano V FIR - Labarga, P IR - Labarga P FIR - Moreno, S IR - Moreno S FIR - Rodriguez, J M IR - Rodriguez J FIR - Clotet, B IR - Clotet B FIR - Jou, A IR - Jou A FIR - Paredes, R IR - Paredes R FIR - Tural, C IR - Tural C FIR - Puig, J IR - Puig J FIR - Bravo, I IR - Bravo I FIR - Gatell, J M IR - Gatell J FIR - Miro, J M IR - Miro J FIR - Domingo, P IR - Domingo P FIR - Gutierrez, M IR - Gutierrez M FIR - Mateo, G IR - Mateo G FIR - Sambeat, M A IR - Sambeat M FIR - Medrano, J IR - Medrano J FIR - Blaxhult, A IR - Blaxhult A FIR - Flamholc, L IR - Flamholc L FIR - Thalme, A IR - Thalme A FIR - Sonnerborg, A IR - Sonnerborg A FIR - Ledergerber, B IR - Ledergerber B FIR - Weber, R IR - Weber R FIR - Francioli, P IR - Francioli P FIR - Cavassini, M IR - Cavassini M FIR - Hirschel, B IR - Hirschel B FIR - Boffi, E IR - Boffi E FIR - Furrer, H IR - Furrer H FIR - Battegay, M IR - Battegay M FIR - Elzi, L IR - Elzi L FIR - Vernazza, P IR - Vernazza P FIR - Kravchenko, E IR - Kravchenko E FIR - Chentsova, N IR - Chentsova N FIR - Frolov, V IR - Frolov V FIR - Kutsyna, G IR - Kutsyna G FIR - Servitskiy, S IR - Servitskiy S FIR - Kuznetsova, A IR - Kuznetsova A FIR - Kyselyova, G IR - Kyselyova G FIR - Gazzard, B IR - Gazzard B FIR - Johnson, A M IR - Johnson A FIR - Mercey, D IR - Mercey D FIR - Phillips, A IR - Phillips A FIR - Johnson, M A IR - Johnson M FIR - Mocroft, A IR - Mocroft A FIR - Orkin, C IR - Orkin C FIR - Weber, J IR - Weber J FIR - Scullard, G IR - Scullard G FIR - Fisher, M IR - Fisher M FIR - Leen, C IR - Leen C FIR - Gatell, J IR - Gatell J FIR - Gazzard, B IR - Gazzard B FIR - Horban, A IR - Horban A FIR - Karpov, I IR - Karpov I FIR - Ledergerber, B IR - Ledergerber B FIR - Losso, M IR - Losso M FIR - Monforte, A D'Arminio IR - Monforte A FIR - Pedersen, C IR - Pedersen C FIR - Rakhmanova, A IR - Rakhmanova A FIR - Lundgren, J IR - Lundgren J FIR - Phillips, A IR - Phillips A FIR - Reiss, P IR - Reiss P FIR - Ristola, M IR - Ristola M FIR - Rockstroh, J IR - Rockstroh J FIR - De Wit, S IR - De Wit S FIR - Kirk, O IR - Kirk O FIR - Mocroft, A IR - Mocroft A FIR - Cozzi-Lepri, A IR - Cozzi-Lepri A FIR - Grint, D IR - Grint D FIR - Schultze, A IR - Schultze A FIR - Shepherd, L IR - Shepherd L FIR - Raben, D IR - Raben D FIR - Podlekareva, D IR - Podlekareva D FIR - Kjaer, J IR - Kjaer J FIR - Peters, L IR - Peters L FIR - Nielsen, J IR - Nielsen J FIR - Tverland, J IR - Tverland J FIR - Fischer, A H IR - Fischer A EDAT- 2013/07/23 06:00 MHDA- 2014/03/08 06:00 CRDT- 2013/07/23 06:00 PHST- 2013/05/21 00:00 [accepted] PHST- 2013/07/23 06:00 [entrez] PHST- 2013/07/23 06:00 [pubmed] PHST- 2014/03/08 06:00 [medline] AID - 10.1111/hiv.12068 [doi] PST - ppublish SO - HIV Med. 2013 Nov;14(10):614-23. doi: 10.1111/hiv.12068. Epub 2013 Jul 19.