PMID- 23869819
OWN - NLM
STAT- MEDLINE
DCOM- 20140512
LR  - 20191210
IS  - 1944-0057 (Electronic)
IS  - 1944-0057 (Linking)
VI  - 30
IP  - 10
DP  - 2013
TI  - Can the unauthorised use of ceftiofur be detected in poultry?
PG  - 1733-8
LID - 10.1080/19440049.2013.814076 [doi]
AB  - Ceftiofur is a third-generation cephalosporin antibiotic used to treat cattle and 
      swine for bacterial infection of the respiratory tract. It is not authorised for 
      use in poultry within the European Union. Due to the complexity of the chemistry 
      and metabolism of ceftiofur, maximum residue limits (MRLs) are based on 
      desfuroylceftiofur (DFC) equivalents after chemical conversion of all compounds 
      that have an intact ss-lactam ring. In practice the DFC is usually stabilised as 
      the acetamide (desfuroylceftiofur acetamide - DFCA) for analysis. Because of 
      recent evidence of off-label use in the European Union, a policy need emerged to 
      develop a cost-effective method for the detection of ceftiofur residues in 
      poultry tissues. One-day-old chicks were each dosed subcutaneously with ceftiofur 
      and samples taken from day 1 to day 44 post-dosing. Residues of ceftiofur parent 
      compound were detected in whole chicks, wing feathers and faeces. On the basis of 
      this finding it was decided to evaluate ceftiofur parent, as the marker, instead 
      of proceeding with the time-consuming conversion to DFCA. Expected metabolites, 
      DFC and desfuroylceftiofur cysteine disulfide (DCCD), were not detected in whole 
      chicks, muscle or liver, but DFC was found in wing feathers. These results 
      indicate that determination of ceftiofur parent compound in either whole chicks 
      or possibly wing feathers and faeces may allow the detection of the misuse of 
      ceftiofur.
FAU - Heinrich, Katharina
AU  - Heinrich K
AD  - a The Food and Environment Research Agency , Sand Hutton , York , UK.
FAU - Chan, Danny
AU  - Chan D
FAU - Fussell, Richard J
AU  - Fussell RJ
FAU - Kay, Jack F
AU  - Kay JF
FAU - Sharman, Matthew
AU  - Sharman M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20130722
PL  - England
TA  - Food Addit Contam Part A Chem Anal Control Expo Risk Assess
JT  - Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & 
      risk assessment
JID - 101485040
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Cephalosporins)
RN  - 83JL932I1C (ceftiofur)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*adverse effects/*analysis
MH  - Cattle
MH  - Cephalosporins/*adverse effects/*analysis
MH  - Chickens
MH  - Drug Residues/adverse effects/analysis
MH  - European Union
MH  - Food Contamination/*analysis
MH  - Humans
MH  - *Poultry
MH  - Tandem Mass Spectrometry
EDAT- 2013/07/23 06:00
MHDA- 2014/05/13 06:00
CRDT- 2013/07/23 06:00
PHST- 2013/07/23 06:00 [entrez]
PHST- 2013/07/23 06:00 [pubmed]
PHST- 2014/05/13 06:00 [medline]
AID - 10.1080/19440049.2013.814076 [doi]
PST - ppublish
SO  - Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(10):1733-8. 
      doi: 10.1080/19440049.2013.814076. Epub 2013 Jul 22.