PMID- 23870824
OWN - NLM
STAT- MEDLINE
DCOM- 20140422
LR  - 20130920
IS  - 1878-3279 (Electronic)
IS  - 0171-2985 (Linking)
VI  - 218
IP  - 11
DP  - 2013 Nov
TI  - Monocyte-derived dendritic cell subpopulations use different types of matrix 
      metalloproteinases inhibited by GM6001.
PG  - 1361-9
LID - S0171-2985(13)00125-3 [pii]
LID - 10.1016/j.imbio.2013.06.012 [doi]
AB  - Matrix metalloproteinases (MMPs) are endopeptidases with the potential to cleave 
      extracellular matrix, support tissue renewal and regulate cell migration. 
      Functional activities of MMPs are regulated by tissue inhibitors of MMPs (TIMPs) 
      and disruption of the MMP-TIMP balance has pathological consequences. Here we 
      studied the expression and secretion of MMPs and TIMPs in CD1a(-) and CD1a(+) 
      monocyte-derived dendritic cell (DC) subpopulations. Our results showed that 
      monocytes express TIMPs but lack MMPs, whereas upon differentiation to moDCs and 
      in response to activation signals the expression of MMPs is increased and that of 
      TIMPs is decreased. MMP-9 is expressed dominantly in the CD1a(-) subpopulation, 
      while MMP-12 is preferentially expressed in CD1a(+) cells. Experiments performed 
      with the synthetic MMP inhibitor GM6001 revealed that this drug efficiently 
      inhibits the migration of moDCs through inactivation of MMPs. We conclude that 
      modulation of MMP activity by GM6001 emerges as a novel approach to manipulate DC 
      migration under inflammatory conditions.
CI  - Copyright (c) 2013 Elsevier GmbH. All rights reserved.
FAU - Kis-Toth, Katalin
AU  - Kis-Toth K
AD  - Department of Immunology, University of Debrecen, Medical and Health Science 
      Center, Debrecen, Hungary; Department of Rheumatology, Beth Israel Deaconess 
      Medical Center, Boston, MA, USA. Electronic address: katakt@gmail.com.
FAU - Bacskai, Ildiko
AU  - Bacskai I
FAU - Gogolak, Peter
AU  - Gogolak P
FAU - Mazlo, Anett
AU  - Mazlo A
FAU - Szatmari, Istvan
AU  - Szatmari I
FAU - Rajnavolgyi, Eva
AU  - Rajnavolgyi E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130702
PL  - Netherlands
TA  - Immunobiology
JT  - Immunobiology
JID - 8002742
RN  - 0 (Antigens, CD1)
RN  - 0 (CD1a antigen)
RN  - 0 (Dipeptides)
RN  - 0 (Matrix Metalloproteinase Inhibitors)
RN  - 0 (N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan 
      methylamide)
RN  - 0 (TIMP1 protein, human)
RN  - 0 (TIMP2 protein, human)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - 127497-59-0 (Tissue Inhibitor of Metalloproteinase-2)
RN  - EC 3.4.24.35 (MMP9 protein, human)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
RN  - EC 3.4.24.65 (MMP12 protein, human)
RN  - EC 3.4.24.65 (Matrix Metalloproteinase 12)
SB  - IM
MH  - Antigens, CD1/metabolism
MH  - Cell Differentiation/immunology
MH  - Cell Movement/*drug effects/immunology
MH  - Cells, Cultured
MH  - Dendritic Cells/*immunology
MH  - Dipeptides/*pharmacology
MH  - Humans
MH  - Inflammation/*immunology
MH  - Matrix Metalloproteinase 12/biosynthesis/metabolism
MH  - Matrix Metalloproteinase 9/biosynthesis/metabolism
MH  - Matrix Metalloproteinase Inhibitors/*pharmacology
MH  - Monocytes
MH  - Tissue Inhibitor of Metalloproteinase-1/biosynthesis/metabolism
MH  - Tissue Inhibitor of Metalloproteinase-2/biosynthesis/metabolism
OTO - NOTNLM
OT  - CD1a
OT  - DC
OT  - Dendritic cell
OT  - IDC
OT  - Immunotherapy
OT  - LCH
OT  - LPS
OT  - Langerhans cell histiocytosis
OT  - MDC
OT  - MMP
OT  - Matrix metalloproteinase
OT  - TIMP
OT  - Tissue inhibitor of matrix metalloproteinase
OT  - dendritic cell
OT  - immature DC
OT  - lipopolysaccharide
OT  - matrix metalloproteinase
OT  - mature DC
OT  - tissue inhibitor of matrix metalloproteinase
EDAT- 2013/07/23 06:00
MHDA- 2014/04/23 06:00
CRDT- 2013/07/23 06:00
PHST- 2013/03/11 00:00 [received]
PHST- 2013/06/19 00:00 [revised]
PHST- 2013/06/24 00:00 [accepted]
PHST- 2013/07/23 06:00 [entrez]
PHST- 2013/07/23 06:00 [pubmed]
PHST- 2014/04/23 06:00 [medline]
AID - S0171-2985(13)00125-3 [pii]
AID - 10.1016/j.imbio.2013.06.012 [doi]
PST - ppublish
SO  - Immunobiology. 2013 Nov;218(11):1361-9. doi: 10.1016/j.imbio.2013.06.012. Epub 
      2013 Jul 2.