PMID- 23871169
OWN - NLM
STAT- MEDLINE
DCOM- 20140530
LR  - 20131018
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 209
IP  - 3
DP  - 2013 Oct 30
TI  - Moving beyond transition outcomes: meta-analysis of remission rates in 
      individuals at high clinical risk for psychosis.
PG  - 266-72
LID - S0165-1781(13)00134-0 [pii]
LID - 10.1016/j.psychres.2013.03.004 [doi]
AB  - Recent evidence suggests that transition risks from initial clinical high risk 
      (CHR) status to psychosis are decreasing. The role played by remission in this 
      context is mostly unknown. The present study addresses this issue by means of a 
      meta-analysis including eight relevant studies published up to January 2012 that 
      reported remission rates from an initial CHR status. The primary effect size 
      measure was the longitudinal proportion of remissions compared to non-remission 
      in subjects with a baseline CHR state. Random effect models were employed to 
      address the high heterogeneity across studies included. To assess the robustness 
      of the results, we performed sensitivity analyses by sequentially removing each 
      study and rerunning the analysis. Of 773 subjects who met initial CHR criteria, 
      73% did not convert to psychosis along a 2-year follow. Of these, about 46% fully 
      remitted from the baseline attenuated psychotic symptoms, as evaluated on the 
      psychometric measures usually employed by prodromal services. The corresponding 
      clinical remission was estimated as high as 35% of the baseline CHR sample. The 
      CHR state is associated with a significant proportion of remitting subjects that 
      can be accounted by the effective treatments received, a lead time bias, a 
      dilution effect, a comorbid effect of other psychiatric diagnoses.
CI  - (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Simon, Andor E
AU  - Simon AE
AD  - University Psychiatry Clinics, University of Basel, 4031 Basel, Switzerland; 
      Specialized Early Psychosis Outpatient Service for Adolescents and Young Adults, 
      Department of Psychiatry, 4101 Bruderholz, Switzerland; University Hospital of 
      Psychiatry, University of Bern, 3010 Bern, Switzerland.
FAU - Borgwardt, Stefan
AU  - Borgwardt S
FAU - Riecher-Rossler, Anita
AU  - Riecher-Rossler A
FAU - Velthorst, Eva
AU  - Velthorst E
FAU - de Haan, Lieuwe
AU  - de Haan L
FAU - Fusar-Poli, Paolo
AU  - Fusar-Poli P
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20130718
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Databases, Factual/statistics & numerical data
MH  - Humans
MH  - *Prodromal Symptoms
MH  - Psychotic Disorders/*epidemiology/*psychology
MH  - Remission, Spontaneous
MH  - Risk Factors
OTO - NOTNLM
OT  - ARMS
OT  - At risk
OT  - Prodromal
OT  - Psychosis
OT  - Schizophrenia
OT  - UHR
EDAT- 2013/07/23 06:00
MHDA- 2014/05/31 06:00
CRDT- 2013/07/23 06:00
PHST- 2012/08/25 00:00 [received]
PHST- 2013/02/24 00:00 [revised]
PHST- 2013/03/03 00:00 [accepted]
PHST- 2013/07/23 06:00 [entrez]
PHST- 2013/07/23 06:00 [pubmed]
PHST- 2014/05/31 06:00 [medline]
AID - S0165-1781(13)00134-0 [pii]
AID - 10.1016/j.psychres.2013.03.004 [doi]
PST - ppublish
SO  - Psychiatry Res. 2013 Oct 30;209(3):266-72. doi: 10.1016/j.psychres.2013.03.004. 
      Epub 2013 Jul 18.