PMID- 23871269
OWN - NLM
STAT- MEDLINE
DCOM- 20140422
LR  - 20151119
IS  - 1872-8464 (Electronic)
IS  - 0165-5876 (Linking)
VI  - 77
IP  - 9
DP  - 2013 Sep
TI  - 1,25(OH)(2)D(3) and specific IgE levels in children with recurrent tonsillitis, and 
      allergic rhinitis.
PG  - 1506-11
LID - S0165-5876(13)00301-7 [pii]
LID - 10.1016/j.ijporl.2013.06.019 [doi]
AB  - OBJECTIVES: We investigated 1,25-dihydroxyvitamin D3 [1,25(OH)(2)D(3)] and specific 
      immunoglobulin E (IgE) levels in children with recurrent tonsillitis (RT) plus 
      allergic rhinitis (AR). METHODS: Thirty children with RT+AR were included in the 
      study group, and 30 healthy children comprised the control group. AR-related 
      symptoms were determined using a symptom scale. 1,25(OH)(2)D(3) and specific IgE 
      measurements were made in both groups. RESULTS: The 1,25(OH)(2)D(3) value was 
      significantly lower in the RT+AR group than in the control group. Specific IgE 
      (mixed) panels were in normal limits in both groups; whereas specific IgE (mixed) 
      grass pollen panel value of RT+AT group was significantly higher than that of the 
      control group. Higher nasal itching, nasal obstruction, and concha edema scores 
      were related to significantly higher specific IgE values for the (mixed) grass 
      pollen panel, whereas higher sneeze scores were related to higher specific IgE 
      values for the (mixed) pediatric panel. CONCLUSIONS: Children with grass pollen 
      allergy may not be exposed to sufficient sunlight. With reduced 1,25(OH)(2)D(3), T 
      helper cells may increase, and allergic response also increases. As allergic 
      events increased, these children did not go outside and thus lacked sun exposure. 
      This vicious cycle must be broken, and children with RT+AR should have sunlight 
      exposure to increase 1,25(OH)(2)D(3) levels.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - San, Turhan
AU  - San T
AD  - Istanbul Medeniyet University, Goztepe Training and Research Hospital, ENT 
      Department , Istanbul, Turkey.
FAU - Muluk, Nuray Bayar
AU  - Muluk NB
FAU - Cingi, Cemal
AU  - Cingi C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20130717
PL  - Ireland
TA  - Int J Pediatr Otorhinolaryngol
JT  - International journal of pediatric otorhinolaryngology
JID - 8003603
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 40013-87-4 (24,25-Dihydroxyvitamin D 3)
SB  - IM
MH  - 24,25-Dihydroxyvitamin D 3/*blood
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/analysis/*blood
MH  - Male
MH  - Pollen/immunology
MH  - Radioimmunoassay
MH  - Recurrence
MH  - Reference Values
MH  - Rhinitis, Allergic
MH  - Rhinitis, Allergic, Perennial/*blood/diagnosis
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Tonsillitis/*blood/diagnosis
OTO - NOTNLM
OT  - 1,25(OH)(2)D(3) level
OT  - Children
OT  - Specific IgE (mixed) grass pollen panel
EDAT- 2013/07/23 06:00
MHDA- 2014/04/23 06:00
CRDT- 2013/07/23 06:00
PHST- 2013/02/20 00:00 [received]
PHST- 2013/06/18 00:00 [revised]
PHST- 2013/06/22 00:00 [accepted]
PHST- 2013/07/23 06:00 [entrez]
PHST- 2013/07/23 06:00 [pubmed]
PHST- 2014/04/23 06:00 [medline]
AID - S0165-5876(13)00301-7 [pii]
AID - 10.1016/j.ijporl.2013.06.019 [doi]
PST - ppublish
SO  - Int J Pediatr Otorhinolaryngol. 2013 Sep;77(9):1506-11. doi: 
      10.1016/j.ijporl.2013.06.019. Epub 2013 Jul 17.