PMID- 23871725
OWN - NLM
STAT- MEDLINE
DCOM- 20140502
LR  - 20130916
IS  - 1873-6300 (Electronic)
IS  - 0891-0618 (Linking)
VI  - 52
DP  - 2013 Sep
TI  - Olfactory bulbectomy induces neuronal rearrangement in the entorhinal cortex in 
      the rat.
PG  - 80-6
LID - S0891-0618(13)00061-6 [pii]
LID - 10.1016/j.jchemneu.2013.07.001 [doi]
AB  - In humans, depression has been associated with disturbances in olfactory 
      circuitry. Symptoms of depression can be mimicked in animals after olfactory 
      bulbectomy (OBX). Animal models of depression-like behavior produce similar 
      neuronal rearrangements in various brain regions as seen in patients affected by 
      depression. We have recently observed that OBX produces neuronal hypotrophy in 
      the piriform cortex (PirC) and CA1 hippocampus as well as decreased adult cell 
      proliferation in the dentate gyrus (DG) of hippocampus. Thus we further evaluated 
      the effects of OBX in neuronal arborization and spine density in brain regions 
      involved in the control of circadian circle, emotion and memory processing such 
      as the prefrontal cortex (PFC), nucleus accumbens (NAcc), infralimbic cortex 
      (ILC), orbitolateral cortex (OLC) and entorhinal cortex (EC). Our present results 
      show that along with severe behavioral deficits observed in these animals, OBX 
      considerably decreased dendritic branching and the total dendritic length in the 
      EC, a major interface of the hippocampus and neocortical regions. The remaining 
      cortices and NAcc were not affected by OBX. Thus, we propose that the lack of 
      input from the olfactory bulbs resulted in serial neuronal rearrangements in the 
      PirC, EC, and hippocampus leading, at least partially, to behavioral deficits in 
      emotion and memory processes.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Morales-Medina, Julio Cesar
AU  - Morales-Medina JC
AD  - Department of Neurology & Neurosurgery, McGill University, Montreal, QC, Canada 
      H4H 1R3; Douglas Mental Health University Institute, McGill University, Montreal, 
      QC, Canada H4H 1R3. Electronic address: julio.morales@mail.mcgill.ca.
FAU - Juarez, Ismael
AU  - Juarez I
FAU - Iannitti, Tommaso
AU  - Iannitti T
FAU - Flores, Gonzalo
AU  - Flores G
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130716
PL  - Netherlands
TA  - J Chem Neuroanat
JT  - Journal of chemical neuroanatomy
JID - 8902615
SB  - IM
MH  - Animals
MH  - Dendritic Spines/physiology
MH  - Entorhinal Cortex/*cytology/*physiology
MH  - Male
MH  - Neurons/physiology
MH  - Olfactory Bulb/*cytology/*physiology
MH  - Olfactory Pathways/*cytology/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Dendritic morphology
OT  - Depression-like behavior
OT  - Golgi-Cox stain
OT  - OBX
EDAT- 2013/07/23 06:00
MHDA- 2014/05/03 06:00
CRDT- 2013/07/23 06:00
PHST- 2013/05/09 00:00 [received]
PHST- 2013/07/07 00:00 [revised]
PHST- 2013/07/07 00:00 [accepted]
PHST- 2013/07/23 06:00 [entrez]
PHST- 2013/07/23 06:00 [pubmed]
PHST- 2014/05/03 06:00 [medline]
AID - S0891-0618(13)00061-6 [pii]
AID - 10.1016/j.jchemneu.2013.07.001 [doi]
PST - ppublish
SO  - J Chem Neuroanat. 2013 Sep;52:80-6. doi: 10.1016/j.jchemneu.2013.07.001. Epub 
      2013 Jul 16.