PMID- 23872095
OWN - NLM
STAT- MEDLINE
DCOM- 20140321
LR  - 20211021
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 551
DP  - 2013 Sep 13
TI  - Progesterone, compared to medroxyprogesterone acetate, to C57BL/6, but not 
      5alpha-reductase mutant, mice enhances object recognition and placement memory and is 
      associated with higher BDNF levels in the hippocampus and cortex.
PG  - 53-7
LID - S0304-3940(13)00634-4 [pii]
LID - 10.1016/j.neulet.2013.07.002 [doi]
AB  - Progesterone (P4) may influence cognition in part through actions of its 
      5alpha-reduced metabolite, allopregnanolone. Ovariectomized mice that were C57BL/6 
      wildtype (WT), or deficient in the 5alpha-reductase Type 1 enzyme (5alpha-reductase 
      knockout; 5alphaRKO), were administered vehicle, P4, allopregnanolone, or 
      medroxyprogesterone acetate (MPA) after training in the object recognition or 
      placement tasks. WT mice administered P4 or allopregnanolone performed 
      significantly better in the object recognition and placement tasks than did WT 
      mice administered vehicle or MPA. 5alphaRKO mice administered allopregnanolone, but 
      not P4, MPA, or vehicle showed enhanced performance in the object recognition and 
      placement tasks. Levels of brain-derived neurotrophic factor (BDNF) in the 
      prefrontal cortex and hippocampus were lowest among mice administered MPA. Thus, 
      some of P4s effects to enhance cognitive performance may be incumbent upon its 
      5alpha-reduction.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Frye, Cheryl A
AU  - Frye CA
AD  - Dept. of Psychology, The University at Albany-SUNY, Albany, NY 12222, USA. 
      cheryl.a.frye@gmail.com
FAU - Koonce, Carolyn J
AU  - Koonce CJ
FAU - Walf, Alicia A
AU  - Walf AA
LA  - eng
GR  - R01 MH067698/MH/NIMH NIH HHS/United States
GR  - R56 MH067698/MH/NIMH NIH HHS/United States
GR  - MH06769801/MH/NIMH NIH HHS/United States
GR  - P20GM103395/GM/NIGMS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130716
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - BXO86P3XXW (Pregnanolone)
RN  - C2QI4IOI2G (Medroxyprogesterone Acetate)
RN  - EC 1.3.1.22 (Cholestenone 5 alpha-Reductase)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cerebral Cortex/metabolism
MH  - Cholestenone 5 alpha-Reductase/*genetics
MH  - Female
MH  - Hippocampus/metabolism
MH  - Medroxyprogesterone Acetate/*pharmacology
MH  - Memory/drug effects/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Ovariectomy
MH  - Pregnanolone/pharmacology
MH  - Progesterone/*pharmacology
MH  - Recognition, Psychology/drug effects/*physiology
PMC - PMC3769780
MID - NIHMS506816
OTO - NOTNLM
OT  - Brain derived neurotrophic factor (BDNF)
OT  - Cognition
OT  - Hormone replacement therapy
OT  - Learning
OT  - Memory
OT  - Neurosteroids
COIS- No conflicts of interest to report.
EDAT- 2013/07/23 06:00
MHDA- 2014/03/22 06:00
PMCR- 2014/09/13
CRDT- 2013/07/23 06:00
PHST- 2012/10/12 00:00 [received]
PHST- 2013/06/24 00:00 [revised]
PHST- 2013/07/02 00:00 [accepted]
PHST- 2013/07/23 06:00 [entrez]
PHST- 2013/07/23 06:00 [pubmed]
PHST- 2014/03/22 06:00 [medline]
PHST- 2014/09/13 00:00 [pmc-release]
AID - S0304-3940(13)00634-4 [pii]
AID - 10.1016/j.neulet.2013.07.002 [doi]
PST - ppublish
SO  - Neurosci Lett. 2013 Sep 13;551:53-7. doi: 10.1016/j.neulet.2013.07.002. Epub 2013 
      Jul 16.