PMID- 23872208
OWN - NLM
STAT- MEDLINE
DCOM- 20140617
LR  - 20220311
IS  - 1532-2742 (Electronic)
IS  - 0163-4453 (Linking)
VI  - 67
IP  - 5
DP  - 2013 Nov
TI  - Characterization of the immune response in human paracoccidioidomycosis.
PG  - 470-85
LID - S0163-4453(13)00203-X [pii]
LID - 10.1016/j.jinf.2013.07.019 [doi]
AB  - OBJECTIVES: Paracoccidioidomycosis (PCM) is a systemic mycosis caused by the 
      dimorphic fungus Paracoccidioides brasiliensis that presents two main clinical 
      forms: the adult form (AF) and the juvenile form (JF); and an asymptomatic form 
      denominated PCM-infection (PI). These forms of PCM are related to the immune 
      response developed after infection, which has been associated with Th1 and Th2 
      responses. However, some PCM characteristics cannot be explained by this balance. 
      In this study we aimed to complement the characterization of the immune response 
      in PCM, including the newly described T cells subpopulations (Th17, Th9 and 
      Th22). METHODS: We analyzed the expression of cytokines and transcription factors 
      characteristics of these different subpopulations of CD4(+) T cells in PBMCs from 
      PCM patients and a PI group. RESULTS: The results showed that the PI group 
      presented a predominant Th1 response; that JF patients were characterized by a 
      mixed Th2/Th9 response; and AF patients were characterized by a predominant 
      Th17/Th22 response, as well as substantial participation of Th1 cells. 
      CONCLUSIONS: These results contribute to the existing knowledge on the immune 
      responses associated with resistance or susceptibility to the P. brasiliensis 
      infection, and thus could lead to the development of new strategies for patient 
      management.
CI  - Copyright (c) 2013 The British Infection Association. Published by Elsevier Ltd. 
      All rights reserved.
FAU - de Castro, Livia Furquim
AU  - de Castro LF
AD  - Department of Clinical Pathology, Faculty of Medical Sciences, University of 
      Campinas (UNICAMP), Campinas, SP, Brazil.
FAU - Ferreira, Maria Carolina
AU  - Ferreira MC
FAU - da Silva, Rosiane Maria
AU  - da Silva RM
FAU - Blotta, Maria Heloisa de Souza Lima
AU  - Blotta MH
FAU - Longhi, Larissa Nara Alegrini
AU  - Longhi LN
FAU - Mamoni, Ronei Luciano
AU  - Mamoni RL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130716
PL  - England
TA  - J Infect
JT  - The Journal of infection
JID - 7908424
RN  - 0 (Cytokines)
SB  - IM
MH  - Analysis of Variance
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Cytokines/immunology
MH  - Humans
MH  - Paracoccidioidomycosis/*immunology/pathology
MH  - T-Lymphocytes, Helper-Inducer/*immunology
MH  - Th1 Cells/immunology
MH  - Th17 Cells/immunology
MH  - Th2 Cells/immunology
OTO - NOTNLM
OT  - Adaptative immune response
OT  - Cytokines
OT  - Paracoccidioidomycosis
OT  - Th1
OT  - Th17
OT  - Th2
EDAT- 2013/07/23 06:00
MHDA- 2014/06/18 06:00
CRDT- 2013/07/23 06:00
PHST- 2013/04/01 00:00 [received]
PHST- 2013/07/02 00:00 [revised]
PHST- 2013/07/03 00:00 [accepted]
PHST- 2013/07/23 06:00 [entrez]
PHST- 2013/07/23 06:00 [pubmed]
PHST- 2014/06/18 06:00 [medline]
AID - S0163-4453(13)00203-X [pii]
AID - 10.1016/j.jinf.2013.07.019 [doi]
PST - ppublish
SO  - J Infect. 2013 Nov;67(5):470-85. doi: 10.1016/j.jinf.2013.07.019. Epub 2013 Jul 
      16.