PMID- 23872387
OWN - NLM
STAT- MEDLINE
DCOM- 20140313
LR  - 20221207
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 59
DP  - 2013 Sep
TI  - Associations between plasma persistent organic pollutant levels and blood 
      pressure in Inuit adults from Nunavik.
PG  - 282-9
LID - S0160-4120(13)00137-2 [pii]
LID - 10.1016/j.envint.2013.06.019 [doi]
AB  - BACKGROUND: Recent evidence suggests that exposure to persistent organic 
      pollutants (POPs) increases the risk of hypertension in environmentally exposed 
      populations. High POP levels have been detected in Arctic populations and the 
      exposure is related to high consumption of fish and marine mammals, which 
      represent the traditional diet of these populations. OBJECTIVE: We examined the 
      associations between polychlorinated biphenyls (PCBs), organochlorine (OC) 
      pesticides and hypertension among Inuit from Nunavik (Quebec, Canada). METHODS: A 
      complete set of data was obtained for 315 Inuit>/=18years who participated in the 
      "Sante Quebec" health survey that was conducted in the 14 villages of Nunavik in 
      1992. Fourteen polychlorinated biphenyls (PCBs) and 8 OC pesticides or their 
      metabolites were measured in plasma samples using gas chromatography with 
      electron capture detection. Blood pressure (BP) was measured using a standardized 
      protocol and information regarding anti-hypertensive medication was obtained 
      through questionnaires. The associations between log-transformed POPs and 
      hypertension (systolic BP>/=140mmHg, diastolic BP>/=90mmHg or anti-hypertensive 
      medication) were analyzed using multiple logistic regressions. RESULTS: Total 
      PCBs as well as the sum of non-dioxin-like PCBs were significantly associated 
      with higher risk of hypertension. Furthermore, the risk of hypertension increased 
      with higher plasma concentrations of congeners 101, 105, 138 and 187. Models 
      adjusted for BP risk factors became significant after including n-3 
      polyunsaturated fatty acids (PUFAs) and further adjustment for lead and mercury 
      did not change the results. Regarding OC pesticides, 
      p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) was associated with increased 
      risk of hypertension while inverse associations were observed with 
      p,p'-dichlorodiphenyltrichloroethane (p,p'-DDT), beta-hexachlorocyclohexane (HCH) 
      and oxychlordane. CONCLUSIONS: Some PCB congeners were associated with higher 
      risk of hypertension in this highly exposed population. Most associations became 
      significant after including n-3 PUFAs in the models. However, the analyses of OC 
      pesticides revealed divergent results, which need to be confirmed in further 
      cohort and experimental studies.
CI  - (c) 2013.
FAU - Valera, Beatriz
AU  - Valera B
AD  - Axe sante publique et pratiques optimales en sante, Centre de recherche du CHU de 
      Quebec, Canada. beatriz.valera@crchul.ulaval.ca
FAU - Ayotte, Pierre
AU  - Ayotte P
FAU - Poirier, Paul
AU  - Poirier P
FAU - Dewailly, Eric
AU  - Dewailly E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130719
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Dioxins)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - 59NEE7PCAB (Hexachlorocyclohexane)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - FXS1BY2PGL (Mercury)
RN  - YM80ODM9PD (beta-hexachlorocyclohexane)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Animals
MH  - Arctic Regions
MH  - Blood Pressure/*drug effects
MH  - Dichlorodiphenyl Dichloroethylene/blood
MH  - Diet
MH  - Dioxins/blood
MH  - *Environmental Exposure
MH  - Environmental Pollutants/*blood
MH  - Fatty Acids, Omega-3/blood
MH  - Female
MH  - Fishes
MH  - Hexachlorocyclohexane/blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/blood
MH  - Hypertension/chemically induced/*epidemiology
MH  - Inuit
MH  - Male
MH  - Mercury/blood
MH  - Middle Aged
MH  - Pesticides/*blood
MH  - Polychlorinated Biphenyls/*blood
MH  - Polychlorinated Dibenzodioxins/blood
MH  - Quebec/epidemiology
MH  - Young Adult
OTO - NOTNLM
OT  - Blood pressure
OT  - Inuit
OT  - Nunavik
OT  - Organochlorine (OC) pesticides
OT  - Persistent organic pollutants (POPs)
OT  - Polychlorinated biphenyls (PCBs)
EDAT- 2013/07/23 06:00
MHDA- 2014/03/14 06:00
CRDT- 2013/07/23 06:00
PHST- 2013/04/26 00:00 [received]
PHST- 2013/06/15 00:00 [revised]
PHST- 2013/06/24 00:00 [accepted]
PHST- 2013/07/23 06:00 [entrez]
PHST- 2013/07/23 06:00 [pubmed]
PHST- 2014/03/14 06:00 [medline]
AID - S0160-4120(13)00137-2 [pii]
AID - 10.1016/j.envint.2013.06.019 [doi]
PST - ppublish
SO  - Environ Int. 2013 Sep;59:282-9. doi: 10.1016/j.envint.2013.06.019. Epub 2013 Jul 
      19.