PMID- 23872609
OWN - NLM
STAT- MEDLINE
DCOM- 20140326
LR  - 20130909
IS  - 1873-4235 (Electronic)
IS  - 0956-5663 (Linking)
VI  - 50
DP  - 2013 Dec 15
TI  - Synergizing nucleic acid aptamers with 1-dimensional nanostructures as label-free 
      field-effect transistor biosensors.
PG  - 278-93
LID - S0956-5663(13)00430-2 [pii]
LID - 10.1016/j.bios.2013.06.033 [doi]
AB  - Since the introduction by Gold et al. in 1990, nucleic acid aptamers had evolved 
      to become a true contender in biosensors for protein and cell detections. 
      Aptamers are short strands of synthetically designed DNA or RNA oligonucleotides 
      that can be self-assembled into unique 3-dimensional structures and can bind to 
      different proteins, cells or even small molecules at a high level of specificity 
      and affinity. In recent years, there had been many reports in literature in using 
      aptamers in place of conventional antibodies as capture biomolecules on the 
      surface. This is mainly due to the better thermal stability properties and ease 
      in production. Consequently, also these characteristics allowed the aptamers to 
      find use in field effect transistors (FETs) based upon 1D nanostructured (1D-NS) 
      as label-free biosensing. In terms of designing label-free platforms for 
      biosensors applications, 1D-NS FET had been an attractive option due to reported 
      high sensitivities toward protein targets arising from the large surface area for 
      detection as well as to their label-free nature. Since the first aptamer-based 
      1D-NS FET biosensor had surfaced in 2005, there had been many more improvements 
      in the overall design and sensitivity in recent years. In this review, the latest 
      developments in synergizing these two interesting areas of research (aptamers and 
      1D-NS FET) will be discussed for a range of different nanowire types as well as 
      for the detection results.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Lung Khung, Yit
AU  - Lung Khung Y
AD  - University of Milan-Bicocca, Department of Materials Science, Via R. Cozzi 53, 
      I-20125 Milan, Italy.
FAU - Narducci, Dario
AU  - Narducci D
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130701
PL  - England
TA  - Biosens Bioelectron
JT  - Biosensors & bioelectronics
JID - 9001289
RN  - 0 (Aptamers, Nucleotide)
SB  - IM
MH  - Animals
MH  - Aptamers, Nucleotide/*chemistry
MH  - Biosensing Techniques/*instrumentation
MH  - Equipment Design
MH  - Humans
MH  - Nanostructures/*chemistry/ultrastructure
MH  - *Transistors, Electronic
OTO - NOTNLM
OT  - Aptamers
OT  - Biosensing
OT  - Field effect transistors
OT  - Nanowires
EDAT- 2013/07/23 06:00
MHDA- 2014/03/29 06:00
CRDT- 2013/07/23 06:00
PHST- 2013/03/08 00:00 [received]
PHST- 2013/06/06 00:00 [revised]
PHST- 2013/06/17 00:00 [accepted]
PHST- 2013/07/23 06:00 [entrez]
PHST- 2013/07/23 06:00 [pubmed]
PHST- 2014/03/29 06:00 [medline]
AID - S0956-5663(13)00430-2 [pii]
AID - 10.1016/j.bios.2013.06.033 [doi]
PST - ppublish
SO  - Biosens Bioelectron. 2013 Dec 15;50:278-93. doi: 10.1016/j.bios.2013.06.033. Epub 
      2013 Jul 1.