PMID- 23873335
OWN - NLM
STAT- MEDLINE
DCOM- 20140401
LR  - 20211021
IS  - 1660-3397 (Electronic)
IS  - 1660-3397 (Linking)
VI  - 11
IP  - 7
DP  - 2013 Jul 18
TI  - Lithothamnion muelleri controls inflammatory responses, target organ injury and 
      lethality associated with graft-versus-host disease in mice.
PG  - 2595-615
LID - 10.3390/md11072595 [doi]
AB  - Lithothamnion muelleri (Hapalidiaceae) is a marine red alga, which is a member of 
      a group of algae with anti-inflammatory, antitumor, and immunomodulatory 
      properties. The present study evaluated the effects of treatment with 
      Lithothamnion muelleri extract (LM) in a model of acute graft-versus-host disease 
      (GVHD), using a model of adoptive splenocyte transfer from C57BL/6 donors into 
      B6D2F1 recipient mice. Mice treated with LM showed reduced clinical signs of 
      disease and mortality when compared with untreated mice. LM-treated mice had 
      reduced tissue injury, less bacterial translocation, and decreased levels of 
      proinflammatory cytokines and chemokines (interferon-gamma (IFN-gamma), tumor necrosis 
      factor-alpha (TNF-alpha), chemokine (C-C motif) ligand 2 (CCL2), chemokine (C-C motif) 
      ligand 3 (CCL3) and chemokine (C-C motif) ligand 5 (CCL5)). The 
      polysaccharide-rich fraction derived from LM could inhibit leukocyte rolling and 
      adhesion in intestinal venules, as assessed by intravital microscopy. LM 
      treatment did not impair the beneficial effects of graft-versus-leukaemia (GVL). 
      Altogether, our studies suggest that treatment with Lithothamnion muelleri has a 
      potential therapeutic application in GVHD treatment.
FAU - Rezende, Barbara M
AU  - Rezende BM
AD  - Laboratory of Resolution of Inflammatory Response, Department of Morphology, 
      Institute of Biological Sciences, Federal University of Minas Gerais, Belo 
      Horizonte, 31270-901, Brazil. babirez@hotmail.com
FAU - Bernardes, Priscila T T
AU  - Bernardes PT
FAU - Resende, Carolina B
AU  - Resende CB
FAU - Arantes, Rosa M E
AU  - Arantes RM
FAU - Souza, Danielle G
AU  - Souza DG
FAU - Braga, Fernao C
AU  - Braga FC
FAU - Castor, Marina G M
AU  - Castor MG
FAU - Teixeira, Mauro M
AU  - Teixeira MM
FAU - Pinho, Vanessa
AU  - Pinho V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130718
PL  - Switzerland
TA  - Mar Drugs
JT  - Marine drugs
JID - 101213729
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/*immunology
MH  - Cell Adhesion/immunology
MH  - Cell Line
MH  - Cytokines/immunology
MH  - Disease Models, Animal
MH  - Endothelial Cells/immunology
MH  - Graft vs Host Disease/*immunology
MH  - Inflammation/*immunology
MH  - Intestines/immunology
MH  - Leukocytes/immunology
MH  - Liver Diseases/immunology
MH  - Macrophages/immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Rhodophyta/*immunology
PMC - PMC3736440
EDAT- 2013/07/23 06:00
MHDA- 2014/04/02 06:00
PMCR- 2013/07/01
CRDT- 2013/07/23 06:00
PHST- 2013/05/03 00:00 [received]
PHST- 2013/07/01 00:00 [revised]
PHST- 2013/07/02 00:00 [accepted]
PHST- 2013/07/23 06:00 [entrez]
PHST- 2013/07/23 06:00 [pubmed]
PHST- 2014/04/02 06:00 [medline]
PHST- 2013/07/01 00:00 [pmc-release]
AID - md11072595 [pii]
AID - marinedrugs-11-02595 [pii]
AID - 10.3390/md11072595 [doi]
PST - epublish
SO  - Mar Drugs. 2013 Jul 18;11(7):2595-615. doi: 10.3390/md11072595.