PMID- 23873660
OWN - NLM
STAT- MEDLINE
DCOM- 20140929
LR  - 20161125
IS  - 1522-726X (Electronic)
IS  - 1522-1946 (Linking)
VI  - 83
IP  - 2
DP  - 2014 Feb
TI  - The long-term outcomes of transcoronary ablation of septal hypertrophy compared 
      to surgical myectomy in patients with symptomatic hypertrophic obstructive 
      cardiomyopathy.
PG  - 270-7
LID - 10.1002/ccd.25134 [doi]
AB  - OBJECTIVES: The aim of this study was to compare the long-term outcomes of 
      transcoronary ablation of septal hypertrophy (TASH) with open surgical myomectomy 
      (SM) in patients with symptomatic hypertrophic obstructive cardiomyopathy (HOCM). 
      METHODS: We reviewed patients who underwent either procedure at our institution. 
      The demographics, clinical outcomes, echocardiographic parameters, and 
      complications were compared. RESULTS: Seventy patients with HOCM were treated 
      with either TASH (n = 47, 26 male) or SM (n = 23, 10 male). Compared to those 
      treated with SM, patients undergoing TASH were older (57+/- 14.7 years versus 47 
      +/- 20.6 years, P = 0.021) and more symptomatic. A higher proportion of patients 
      had syncope as a presenting feature in the TASH group compared to the SM group 
      (57.5% vs. 17.4%, P = 0.002) respectively. They were also more likely to be in 
      New York Heart Association (NYHA) class III/IV compared to the patients who 
      underwent SM (85.1% vs. 39.1%; P < 0.001). Patients were followed for a mean 
      period of 43 months (TASH) and 46 months (SM). Repeat procedures were more common 
      in the TASH group (17% vs. 0%, P = 0.04) but mitral valve replacement was more 
      common in the SM group (0% vs. 8.7%, P = 0.105). Symptom improvement, the rate of 
      complications and all cause mortality rates were similar in both groups. 
      CONCLUSIONS: TASH compares favorably with surgical myectomy with regard to 
      symptom resolution, rate of complications and mortality in a tertiary referral 
      centre and should be seen as an attractive alternative to surgical myectomy in 
      the appropriate patient population.
CI  - Copyright (c) 2013 Wiley Periodicals, Inc.
FAU - Samardhi, Himabindu
AU  - Samardhi H
AD  - The Prince Charles Hospital, Rode Road, Chermside, Brisbane, Queensland, 4032, 
      Australia; University of Queensland, Australia.
FAU - Walters, Darren L
AU  - Walters DL
FAU - Raffel, Christopher
AU  - Raffel C
FAU - Rateesh, Shruti
AU  - Rateesh S
FAU - Harley, Catherine
AU  - Harley C
FAU - Burstow, Darryl
AU  - Burstow D
FAU - Pohlner, Peter
AU  - Pohlner P
FAU - Aroney, Con
AU  - Aroney C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20130831
PL  - United States
TA  - Catheter Cardiovasc Interv
JT  - Catheterization and cardiovascular interventions : official journal of the 
      Society for Cardiac Angiography & Interventions
JID - 100884139
RN  - 3K9958V90M (Ethanol)
SB  - IM
CIN - Catheter Cardiovasc Interv. 2014 Feb;83(2):278-9. PMID: 24446325
MH  - *Ablation Techniques/adverse effects/mortality
MH  - Adult
MH  - Aged
MH  - Cardiac Surgical Procedures/adverse effects/mortality
MH  - Cardiomyopathy, 
      Hypertrophic/complications/diagnosis/mortality/physiopathology/*surgery
MH  - Ethanol/*administration & dosage
MH  - Female
MH  - Heart Septum/diagnostic imaging/physiopathology/*surgery
MH  - Hemodynamics
MH  - Humans
MH  - Hypertrophy
MH  - Male
MH  - Middle Aged
MH  - Patient Selection
MH  - Postoperative Complications/mortality/surgery
MH  - Reoperation
MH  - Risk Factors
MH  - Syncope/etiology
MH  - Tertiary Care Centers
MH  - Time Factors
MH  - Treatment Outcome
MH  - Ultrasonography
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - ANGO
OT  - HCM
OT  - septal ablation
EDAT- 2013/07/23 06:00
MHDA- 2014/09/30 06:00
CRDT- 2013/07/23 06:00
PHST- 2012/09/17 00:00 [received]
PHST- 2013/05/30 00:00 [revised]
PHST- 2013/07/11 00:00 [accepted]
PHST- 2013/07/23 06:00 [entrez]
PHST- 2013/07/23 06:00 [pubmed]
PHST- 2014/09/30 06:00 [medline]
AID - 10.1002/ccd.25134 [doi]
PST - ppublish
SO  - Catheter Cardiovasc Interv. 2014 Feb;83(2):270-7. doi: 10.1002/ccd.25134. Epub 
      2013 Aug 31.