PMID- 23874758
OWN - NLM
STAT- MEDLINE
DCOM- 20140331
LR  - 20211021
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 7
DP  - 2013
TI  - Lifelong caloric restriction increases working memory in mice.
PG  - e68778
LID - 10.1371/journal.pone.0068778 [doi]
LID - e68778
AB  - Caloric restriction (CR) is argued to positively affect general health, longevity 
      and the normally occurring age-related reduction of cognition. This issue is well 
      examined, but most studies investigated the effect of short-term periods of CR. 
      Herein, 4 weeks old female mice were fed caloric restricted for 4, 20 and 
      especially for 74 weeks. CR mice received 60% of food eaten by their ad libitum 
      (AL) fed littermates, and all age-matched groups were behaviorally analyzed. The 
      motor coordination, which was tested by rotarod/accelerod, decreased age-related, 
      but was not influenced by the different periods of CR. In contrast, the 
      age-related impairment of spontaneous locomotor activity and anxiety, both being 
      evaluated by open field and by elevated plus maze test, was found aggravated by a 
      lifelong CR. Measurement of cognitive performance with morris water maze showed 
      that the working memory decreased age-related in AL mice, while a lifelong CR 
      caused a better cognitive performance and resulted in a significantly better 
      spatial memory upon 74 weeks CR feeding. However, a late-onset CR feeding in 66 
      weeks old mice did not ameliorate the working memory. Therefore, a lifelong CR 
      seems to be necessary to improve working memory.
FAU - Kuhla, Angela
AU  - Kuhla A
AD  - Institute for Experimental Surgery, University of Rostock, Rostock, Germany. 
      angela.kuhla@uni-rostock.de
FAU - Lange, Sophie
AU  - Lange S
FAU - Holzmann, Carsten
AU  - Holzmann C
FAU - Maass, Fabian
AU  - Maass F
FAU - Petersen, Jana
AU  - Petersen J
FAU - Vollmar, Brigitte
AU  - Vollmar B
FAU - Wree, Andreas
AU  - Wree A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130710
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Animals
MH  - Anxiety/etiology
MH  - Behavior, Animal/physiology
MH  - Body Weight/physiology
MH  - *Caloric Restriction/psychology
MH  - Female
MH  - Growth and Development/physiology
MH  - Longevity/physiology
MH  - Maze Learning/physiology
MH  - Memory, Short-Term/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Motor Activity/physiology
MH  - Swimming
PMC - PMC3707851
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/07/23 06:00
MHDA- 2014/04/01 06:00
PMCR- 2013/07/10
CRDT- 2013/07/23 06:00
PHST- 2012/08/31 00:00 [received]
PHST- 2013/06/04 00:00 [accepted]
PHST- 2013/07/23 06:00 [entrez]
PHST- 2013/07/23 06:00 [pubmed]
PHST- 2014/04/01 06:00 [medline]
PHST- 2013/07/10 00:00 [pmc-release]
AID - PONE-D-12-26639 [pii]
AID - 10.1371/journal.pone.0068778 [doi]
PST - epublish
SO  - PLoS One. 2013 Jul 10;8(7):e68778. doi: 10.1371/journal.pone.0068778. Print 2013.