PMID- 23875616
OWN - NLM
STAT- MEDLINE
DCOM- 20140929
LR  - 20181202
IS  - 1464-5246 (Electronic)
IS  - 0265-2048 (Linking)
VI  - 31
IP  - 2
DP  - 2014
TI  - Co-encapsulation of human serum albumin and superparamagnetic iron oxide in PLGA 
      nanoparticles: part I. Effect of process variables on the mean size.
PG  - 147-55
LID - 10.3109/02652048.2013.814729 [doi]
AB  - PLGA (poly d,l-lactic-co-glycolic acid) nanoparticles (NPs) encapsulating 
      magnetite nanoparticles (MNPs) along with a model drug human serum albumin (HSA) 
      were prepared by double emulsion solvent evaporation method. This Part I will 
      focus on size and size distribution of prepared NPs, whereas encapsulation 
      efficiency will be discussed in Part II. It was found that mean hydrodynamic 
      particle size was influenced by five important process variables. To explore 
      their effects, a five-factorial, three-level experimental design and statistical 
      analysis were carried out using STATISTICA(R) software. Effect of process variables 
      on the mean size of nanoparticles was investigated and finally conditions to 
      minimize size of NPs were proposed. GAMS/MINOS software was used for 
      optimization. The mean hydrodynamic size of nanoparticles ranged from 115 to 
      329 nm depending on the process conditions. Smallest possible mean particle size 
      can be achieved by using low polymer concentration and high dispersion energy 
      (enough sonication time) along with small aqueous/organic volume ratio.
FAU - Shubhra, Quazi T H
AU  - Shubhra QT
AD  - Doctoral School of Molecular and Nanotechnologies, Faculty of Information 
      Technology, University of Pannonia , Egyetem u.10, H-8200 Veszprem , Hungary .
FAU - Kardos, Andrea F
AU  - Kardos AF
FAU - Feczko, Tivadar
AU  - Feczko T
FAU - Mackova, Hana
AU  - Mackova H
FAU - Horak, Daniel
AU  - Horak D
FAU - Toth, Judit
AU  - Toth J
FAU - Dosa, Gyorgy
AU  - Dosa G
FAU - Gyenis, Janos
AU  - Gyenis J
LA  - eng
PT  - Journal Article
DEP - 20130722
PL  - England
TA  - J Microencapsul
JT  - Journal of microencapsulation
JID - 8500513
RN  - 0 (Ferric Compounds)
RN  - 0 (Serum Albumin)
RN  - 1K09F3G675 (ferric oxide)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Ferric Compounds/*chemistry
MH  - Humans
MH  - Lactic Acid/*chemistry
MH  - Nanoparticles/*chemistry/ultrastructure
MH  - Particle Size
MH  - Polyglycolic Acid/*chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Serum Albumin/*chemistry
EDAT- 2013/07/24 06:00
MHDA- 2014/09/30 06:00
CRDT- 2013/07/24 06:00
PHST- 2013/07/24 06:00 [entrez]
PHST- 2013/07/24 06:00 [pubmed]
PHST- 2014/09/30 06:00 [medline]
AID - 10.3109/02652048.2013.814729 [doi]
PST - ppublish
SO  - J Microencapsul. 2014;31(2):147-55. doi: 10.3109/02652048.2013.814729. Epub 2013 
      Jul 22.