PMID- 23876350
OWN - NLM
STAT- MEDLINE
DCOM- 20140428
LR  - 20130909
IS  - 2210-741X (Electronic)
IS  - 2210-7401 (Linking)
VI  - 37
IP  - 4
DP  - 2013 Sep
TI  - Benign hepatocellular nodules: what have we learned using the patho-molecular 
      classification.
PG  - 322-7
LID - S2210-7401(13)00129-0 [pii]
LID - 10.1016/j.clinre.2013.04.008 [doi]
AB  - Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) are benign 
      hepatocellular tumors that develop most frequently in females and in 
      non-cirrhotic livers. HCA are prone to bleed and to transform into hepatocellular 
      carcinoma (HCC). Four major subgroups of HCA have been thus far identified: HNF1alpha 
      mutated HCA, inflammatory HCA (IHCA), beta-catenin mutated HCA (b-HCA and b-IHCA), 
      based on mutations in specific oncogenes and tumor suppressors. B-HCA and b-IHCA 
      are strongly associated with HCC transformation. Benign hepatocellular tumors can 
      be classified using immunohistochemistry (LFABP, CRP, GS, b-catenin). Analysis of 
      HCA phenotypes has led to the identification of patients at risk of HCC 
      transformation and therefore improved the indications provided by invasive and 
      non-invasive diagnostic techniques, such as biopsies and MRI. These recent 
      advances have broadened the clinical scope of HCA in various conditions, such as 
      their presence in males, in obese patients, in patients suffering from liver 
      vascular disorders, genetic diseases. However, specific immunohistochemistry has 
      shown limitations particularly for the identification of b-HCA, thereby, 
      outlining the importance of molecular studies to improve the diagnosis/prognosis 
      of HCA. If evaluation of prognosis and treatment has benefited from these 
      advances, much more needs to be done to obtain guidelines for good clinical 
      practice.
CI  - Copyright (c) 2013 Elsevier Masson SAS. All rights reserved.
FAU - Sempoux, Christine
AU  - Sempoux C
AD  - Service d'Anatomie Pathologique, Cliniques universitaires Saint-Luc, Universite 
      catholique de Louvain, 1200 Brussels, Belgium. christine.sempoux@uclouvain.be
FAU - Chang, Charissa
AU  - Chang C
FAU - Gouw, Annette
AU  - Gouw A
FAU - Chiche, Laurence
AU  - Chiche L
FAU - Zucman-Rossi, Jessica
AU  - Zucman-Rossi J
FAU - Balabaud, Charles
AU  - Balabaud C
FAU - Bioulac-Sage, Paulette
AU  - Bioulac-Sage P
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130719
PL  - France
TA  - Clin Res Hepatol Gastroenterol
JT  - Clinics and research in hepatology and gastroenterology
JID - 101553659
SB  - IM
MH  - Adenoma, Liver Cell/*classification/*pathology
MH  - Humans
EDAT- 2013/07/24 06:00
MHDA- 2014/04/29 06:00
CRDT- 2013/07/24 06:00
PHST- 2013/02/19 00:00 [received]
PHST- 2013/04/04 00:00 [revised]
PHST- 2013/04/05 00:00 [accepted]
PHST- 2013/07/24 06:00 [entrez]
PHST- 2013/07/24 06:00 [pubmed]
PHST- 2014/04/29 06:00 [medline]
AID - S2210-7401(13)00129-0 [pii]
AID - 10.1016/j.clinre.2013.04.008 [doi]
PST - ppublish
SO  - Clin Res Hepatol Gastroenterol. 2013 Sep;37(4):322-7. doi: 
      10.1016/j.clinre.2013.04.008. Epub 2013 Jul 19.