PMID- 23876597
OWN - NLM
STAT- MEDLINE
DCOM- 20140317
LR  - 20211021
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 121
IP  - 9
DP  - 2013 Sep
TI  - Perinatally administered bisphenol a as a potential mammary gland carcinogen in 
      rats.
PG  - 1040-6
LID - 10.1289/ehp.1306734 [doi]
AB  - BACKGROUND: Environmental exposure to bisphenol A (BPA) affects mammary gland 
      development in rodents and primates. Prenatal exposure to environmentally 
      relevant doses of BPA increased the number of intraductal hyperplasias and ductal 
      carcinomas in situ by 50 days of age in Wistar-Furth rats. OBJECTIVE: We aimed to 
      determine whether BPA exposure of dams during gestation only or throughout 
      lactation affects the incidence of mammary gland neoplasia in female offspring. 
      METHODS: We treated pregnant Sprague-Dawley rats with BPA at 0, 0.25, 2.5, 25, or 
      250 mug BPA/kg BW/day from gestational day (GD) 9 to birth and from GD9 to 
      postnatal day (PND) 21. Mammary glands from BPA-exposed offspring were examined 
      at four time points for preneoplastic and neoplastic lesions. To assess 
      circulating BPA levels, we exposed pregnant rats to vehicle or 250 mug BPA/kg 
      BW/day during gestation only or during gestation/lactation and analyzed sera from 
      dams, fetuses, and nursing pups for total and unconjugated BPA. RESULTS: Total 
      and unconjugated BPA were detected in sera from 100% of dams and fetuses and 33% 
      of pups exposed to 250 mug BPA/kg BW/day. Unconjugated BPA levels in exposed dams 
      and fetuses (gestational) and in exposed dams and pups (gestational/lactational) 
      were within levels found in humans. Preneoplastic lesions developed in 
      BPA-exposed female offspring across all doses as early as PND50. Unexpectedly, 
      mammary gland adenocarcinomas developed in BPA-exposed offspring by PND90. 
      CONCLUSIONS: Our findings suggest that developmental exposure to environmentally 
      relevant levels of BPA during gestation and lactation induces mammary gland 
      neoplasms in the absence of any additional carcinogenic treatment. Thus, BPA may 
      act as a complete mammary gland carcinogen.
FAU - Acevedo, Nicole
AU  - Acevedo N
AD  - Department of Anatomy and Cellular Biology, Tufts University School of Medicine, 
      Boston, MA 02111, USA.
FAU - Davis, Barbara
AU  - Davis B
FAU - Schaeberle, Cheryl M
AU  - Schaeberle CM
FAU - Sonnenschein, Carlos
AU  - Sonnenschein C
FAU - Soto, Ana M
AU  - Soto AM
LA  - eng
GR  - R01 ES008314/ES/NIEHS NIH HHS/United States
GR  - RC2 ES018822/ES/NIEHS NIH HHS/United States
GR  - R01ES08314/ES/NIEHS NIH HHS/United States
GR  - RC2ES018822/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20130723
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Carcinogens, Environmental)
RN  - 0 (Phenols)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
CIN - Environ Health Perspect. 2013 Sep;121(9):A284. PMID: 24004942
MH  - Animals
MH  - Benzhydryl Compounds/administration & dosage/blood/*toxicity
MH  - Carcinogens, Environmental/administration & dosage/*toxicity
MH  - Carcinoma, Ductal/*chemically induced
MH  - Environmental Exposure/*adverse effects
MH  - Female
MH  - Hyperplasia/*chemically induced
MH  - Mammary Neoplasms, Animal/*chemically induced
MH  - Phenols/administration & dosage/blood/*toxicity
MH  - Pregnancy
MH  - Rats
MH  - Rats, Inbred WF
MH  - Rats, Sprague-Dawley
PMC - PMC3764091
COIS- The findings and conclusions in this report are those of the authors and do not 
      necessarily represent the views of the NIEHS or NIH. The authors declare they 
      have no actual or potential competing financial interests.
EDAT- 2013/07/24 06:00
MHDA- 2014/03/19 06:00
PMCR- 2013/09/01
CRDT- 2013/07/24 06:00
PHST- 2013/03/01 00:00 [received]
PHST- 2013/06/28 00:00 [accepted]
PHST- 2013/07/24 06:00 [entrez]
PHST- 2013/07/24 06:00 [pubmed]
PHST- 2014/03/19 06:00 [medline]
PHST- 2013/09/01 00:00 [pmc-release]
AID - ehp.1306734 [pii]
AID - 10.1289/ehp.1306734 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2013 Sep;121(9):1040-6. doi: 10.1289/ehp.1306734. Epub 
      2013 Jul 23.