PMID- 23876786
OWN - NLM
STAT- MEDLINE
DCOM- 20140422
LR  - 20130910
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 46
DP  - 2013 Oct 1
TI  - BDNF val66met modulates the association between childhood trauma, cognitive and 
      brain abnormalities in psychoses.
PG  - 181-8
LID - S0278-5846(13)00149-8 [pii]
LID - 10.1016/j.pnpbp.2013.07.008 [doi]
AB  - OBJECTIVE: Brain derived neurotrophic factor (BDNF) is important for brain 
      development and plasticity, and here we tested if the functional BDNF val66met 
      variant modulates the association between high levels of childhood abuse, 
      cognitive function, and brain abnormalities in psychoses. METHOD: 249 patients 
      with a broad DSM-IV schizophrenia spectrum disorder or bipolar disorder were 
      consecutively recruited to the TOP research study (mean+/-age: 30.7+/-10.9; gender: 
      49% males). History of childhood trauma was obtained using the Childhood Trauma 
      Questionnaire. Cognitive function was assessed through a standardized 
      neuropsychological test battery. BDNF val66met was genotyped using standardized 
      procedures. A sub-sample of n=106 Caucasians with a broad DSM-IV schizophrenia 
      spectrum disorder or bipolar disorder (mean+/-age: 32.67+/-10.85; 49% males) had data 
      on sMRI. RESULTS: Carriers of the Methionine (met) allele exposed to high level 
      of childhood abuse demonstrated significantly poorer cognitive functioning 
      compared to homozygotic Valine (val/val) carriers. Taking in consideration 
      multiple testing, using a more conservative p value, this was still shown for 
      physical abuse and emotional abuse, as well as a trend level for sexual abuse. 
      Further, met carriers exposed to high level of childhood sexual abuse showed 
      reduced right hippocampal volume (r(2)=0.43; p=0.008), and larger right and left 
      lateral ventricles (r(2)=0.37; p=0.002, and r(2)=0.27; p=0.009, respectively). 
      Our findings were independent of age, gender, diagnosis and intracranial volume. 
      CONCLUSION: Our data demonstrate that in patients with psychoses, met carriers of 
      the BDNF val66met with high level of childhood abuse have more cognitive and 
      brain abnormalities than all other groups.
CI  - (c) 2013.
FAU - Aas, Monica
AU  - Aas M
AD  - Institute of Clinical Medicine, University of Oslo, Norway; Psychosis Research 
      Unit, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, 
      Norway. Electronic address: monica.aas@medisin.uio.no.
FAU - Haukvik, Unn K
AU  - Haukvik UK
FAU - Djurovic, Srdjan
AU  - Djurovic S
FAU - Bergmann, Orjan
AU  - Bergmann O
FAU - Athanasiu, Lavinia
AU  - Athanasiu L
FAU - Tesli, Martin S
AU  - Tesli MS
FAU - Hellvin, Tone
AU  - Hellvin T
FAU - Steen, Nils Eiel
AU  - Steen NE
FAU - Agartz, Ingrid
AU  - Agartz I
FAU - Lorentzen, Steinar
AU  - Lorentzen S
FAU - Sundet, Kjetil
AU  - Sundet K
FAU - Andreassen, Ole A
AU  - Andreassen OA
FAU - Melle, Ingrid
AU  - Melle I
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20130719
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Bipolar Disorder/diagnosis/genetics/psychology
MH  - Brain/pathology
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - *Child Abuse/diagnosis/psychology
MH  - Cognition Disorders/diagnosis/*genetics/psychology
MH  - Hippocampus/*pathology
MH  - Humans
MH  - Lateral Ventricles/*pathology
MH  - Methionine/genetics
MH  - Psychotic Disorders/diagnosis/*genetics/psychology
MH  - Valine/genetics
MH  - Young Adult
OTO - NOTNLM
OT  - BDNF
OT  - BDNF val66met
OT  - Bipolar NOS
OT  - Bipolar Not Otherwise Specified
OT  - Brain derived neurotrophic factor
OT  - CTQ
OT  - Childhood Trauma Questionnaire
OT  - Cognition
OT  - D-KEFS
OT  - DNA
OT  - DSM-IV
OT  - Delis-Kaplan Executive Function Scale
OT  - Deoxyribonucleic acid
OT  - Diagnostic and Statistical Manual of Mental Disorders, fourth edition
OT  - EA
OT  - EN
OT  - Early trauma
OT  - GR
OT  - Genexenvironmental interaction
OT  - IQ
OT  - PA
OT  - PANSS
OT  - PASW
OT  - PN
OT  - Positive and Negative Syndrome Scale
OT  - Precursor of brain-derived neurotrophic factor
OT  - Predictive Analytic software
OT  - Psychoses
OT  - Psychosis NOS
OT  - Psychosis Not Otherwise specified
OT  - RNA
OT  - Ribonucleic acid
OT  - SA
OT  - SCID
OT  - SNP
OT  - Structured Clinical Interview for DSM Disorders
OT  - TOP study
OT  - Thematically Organized Psychosis research study
OT  - WASI
OT  - Wechsler Abbreviated Scale of Intelligence
OT  - emotional abuse
OT  - emotional neglect
OT  - glucocorticoid receptor
OT  - intelligence quotient
OT  - met
OT  - methionine
OT  - physical abuse
OT  - physical neglect
OT  - proBDNF
OT  - sMRI
OT  - sexual abuse
OT  - single-nucleotide polymorphism
OT  - structural magnetic resonance imaging
OT  - val
OT  - valine
EDAT- 2013/07/24 06:00
MHDA- 2014/04/23 06:00
CRDT- 2013/07/24 06:00
PHST- 2013/03/14 00:00 [received]
PHST- 2013/07/03 00:00 [revised]
PHST- 2013/07/10 00:00 [accepted]
PHST- 2013/07/24 06:00 [entrez]
PHST- 2013/07/24 06:00 [pubmed]
PHST- 2014/04/23 06:00 [medline]
AID - S0278-5846(13)00149-8 [pii]
AID - 10.1016/j.pnpbp.2013.07.008 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2013 Oct 1;46:181-8. doi: 
      10.1016/j.pnpbp.2013.07.008. Epub 2013 Jul 19.