PMID- 23876883
OWN - NLM
STAT- MEDLINE
DCOM- 20140430
LR  - 20161125
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Linking)
VI  - 126
IP  - 14
DP  - 2013 Jul
TI  - Left ventricular 12 segmental strain imaging predicts response to cardiac 
      resynchronization therapy.
PG  - 2620-4
AB  - BACKGROUND: The number of non-responders to cardiac resynchronization therapy 
      (CRT) exposes the need for better patient selection criteria for CRT. This study 
      aimed to identify echocardiographic parameters that would predict the response to 
      CRT. METHODS: Forty-five consecutive patients receiving CRT-D implantation for 
      heart failure (HF) were included in this prospective study. New York Heart 
      Association (NYHA) class, 6-minute walk distance, electrograph character, and 
      multi echocardiographic parameters, especially in strain patterns, were measured 
      and compared before and six months after CRT in the responder and non-responder 
      groups. Response to CRT was defined as a decrease in left ventricular endsystolic 
      volume (LVESV) of 15% or more at 6-month follow up. RESULTS: Twenty-two (48.9%) 
      patients demonstrated a response to CRT at 6-month follow-up. Significant 
      improvement in NYHA class (P < 0.01), left ventricular end-diastolic volume 
      (LVEDV) (P < 0.01), and 6-minute walk distance (P < 0.01) was shown in this 
      group. Although there was an interventricular mechanical delay determined by the 
      difference between left and right ventricular pre-ejection intervals ((42.87 +/- 
      19.64) ms vs. (29.43 +/- 18.19) ms, P = 0.02), the standard deviation of time to 
      peak myocardial strain among 12 basal, mid and apical segments (Tepsilon-SD) ((119.97 +/- 
      43.32) ms vs. (86.62 +/- 36.86) ms, P = 0.01) and the non-ischemic etiology (P = 
      0.03) were significantly higher in responders than non-responders, only the Tepsilon-SD 
      (OR = 1.02, 95% CI = 1.01 - 1.04, P = 0.02) proved to be a favorable predictor of 
      CRT response after multivariate Logistic regression analysis. CONCLUSION: The 
      left ventricular 12 segmental strain imaging is a promising echocardiographic 
      parameter for predicting CRT response.
FAU - Dong, Ying-Xue
AU  - Dong YX
AD  - Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN, USA.
FAU - Oh, Jae K
AU  - Oh JK
FAU - Yang, Yan-Zong
AU  - Yang YZ
FAU - Cha, Yong-Mei
AU  - Cha YM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
SB  - IM
MH  - Aged
MH  - *Cardiac Resynchronization Therapy
MH  - Echocardiography
MH  - Female
MH  - Heart Failure/diagnostic imaging/physiopathology/*therapy
MH  - Heart Ventricles/*physiopathology
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
EDAT- 2013/07/24 06:00
MHDA- 2014/05/03 06:00
CRDT- 2013/07/24 06:00
PHST- 2013/07/24 06:00 [entrez]
PHST- 2013/07/24 06:00 [pubmed]
PHST- 2014/05/03 06:00 [medline]
PST - ppublish
SO  - Chin Med J (Engl). 2013 Jul;126(14):2620-4.