PMID- 23878590
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130723
LR  - 20211021
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2013
DP  - 2013
TI  - Flavonoids induce the synthesis and secretion of neurotrophic factors in cultured 
      rat astrocytes: a signaling response mediated by estrogen receptor.
PG  - 127075
LID - 10.1155/2013/127075 [doi]
LID - 127075
AB  - Neurotrophic factors are playing vital roles in survival, growth, and function of 
      neurons. Regulation of neurotrophic factors in the brain has been considered as 
      one of the targets in developing drug or therapy against neuronal disorders. 
      Flavonoids, a family of multifunctional natural compounds, are well known for 
      their neuronal beneficial effects. Here, the effects of flavonoids on regulating 
      neurotrophic factors were analyzed in cultured rat astrocytes. Astrocyte is a 
      major secreting source of neurotrophic factors in the brain. Thirty-three 
      flavonoids were screened in the cultures, and calycosin, isorhamnetin, luteolin, 
      and genistein were identified to be highly active in inducing the synthesis and 
      secretion of neurotrophic factors, including nerve growth factor (NGF), 
      glial-derived neurotrophic factor (GDNF), and brain-derived neurotrophic factor 
      (BDNF). The inductions were in time- and dose-dependent manners. In cultured 
      astrocytes, the phosphorylation of estrogen receptor was triggered by application 
      of flavonoids. The phosphorylation was blocked by an inhibitor of estrogen 
      receptor, which in parallel reduced the flavonoid-induced expression of 
      neurotrophic factors. The results proposed the role of flavonoids in protecting 
      brain diseases, and therefore these flavonoids could be developed for health food 
      supplement for patients suffering from neurodegenerative diseases.
FAU - Xu, Sherry L
AU  - Xu SL
AD  - Division of Life Science and Center for Chinese Medicine, The Hong Kong 
      University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong.
FAU - Bi, Cathy W C
AU  - Bi CW
FAU - Choi, Roy C Y
AU  - Choi RC
FAU - Zhu, Kevin Y
AU  - Zhu KY
FAU - Miernisha, Abudureyimu
AU  - Miernisha A
FAU - Dong, Tina T X
AU  - Dong TT
FAU - Tsim, Karl W K
AU  - Tsim KW
LA  - eng
PT  - Journal Article
DEP - 20130625
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC3708423
EDAT- 2013/07/24 06:00
MHDA- 2013/07/24 06:01
PMCR- 2013/06/25
CRDT- 2013/07/24 06:00
PHST- 2013/04/23 00:00 [received]
PHST- 2013/05/30 00:00 [revised]
PHST- 2013/06/10 00:00 [accepted]
PHST- 2013/07/24 06:00 [entrez]
PHST- 2013/07/24 06:00 [pubmed]
PHST- 2013/07/24 06:01 [medline]
PHST- 2013/06/25 00:00 [pmc-release]
AID - 10.1155/2013/127075 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2013;2013:127075. doi: 10.1155/2013/127075. 
      Epub 2013 Jun 25.