PMID- 23879572
OWN - NLM
STAT- MEDLINE
DCOM- 20141021
LR  - 20180816
IS  - 1468-1331 (Electronic)
IS  - 1351-5101 (Linking)
VI  - 21
IP  - 1
DP  - 2014
TI  - Serum brain-derived neurotrophic factor levels in epilepsy.
PG  - 57-64
LID - 10.1111/ene.12232 [doi]
AB  - BACKGROUND AND PURPOSE: To clarify the utility of serum brain-derived 
      neurotrophic factor (BDNF) as a biomarker for epilepsy diagnosis and severity. 
      METHODS: Serum BDNF levels in 135 consecutive people with epilepsy meeting our 
      criteria were assessed. Controls were 34 healthy individuals who over 12 months 
      or longer had no complaints or signs of a neurological disorder. Serum BDNF 
      concentrations were measured using Luminex technology. RESULTS: Gender, but not 
      age, was found to be a significant factor related to serum BDNF levels in 
      controls and people with epilepsy. Serum BDNF levels in people with epilepsy 
      (mean 8798.5, SE 321.5 pg/ml) were not different from those of controls (mean 
      8919.5, SE 709.0 pg/ml). A multiple linear regression analysis, however, suggests 
      that seizure frequency (P < 0.001) and epilepsy duration (P = 0.025) negatively 
      correlate with serum BDNF levels independently of other factors. When BDNF 
      cut-off values of 6260 pg/ml were used, the sensitivity for distinguishing people 
      with daily or more frequent seizures from those with fewer seizures was 80% and 
      specificity was 90%. CONCLUSIONS: It seems that the concentration of BDNF in 
      serum is associated with disease severity in people with epilepsy and may be a 
      helpful marker for severity.
CI  - (c) 2013 The Author(s) European Journal of Neurology (c) 2013 EFNS.
FAU - Hong, Z
AU  - Hong Z
AD  - Department of Neurology, West China Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Li, W
AU  - Li W
FAU - Qu, B
AU  - Qu B
FAU - Zou, X
AU  - Zou X
FAU - Chen, J
AU  - Chen J
FAU - Sander, J W
AU  - Sander JW
FAU - Zhou, D
AU  - Zhou D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130723
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biomarkers/*blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Child
MH  - Epilepsy/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Young Adult
OTO - NOTNLM
OT  - Luminex
OT  - biomarker
OT  - brain-derived neurotrophic factor
OT  - epilepsy
OT  - serum
EDAT- 2013/07/25 06:00
MHDA- 2014/10/22 06:00
CRDT- 2013/07/25 06:00
PHST- 2013/05/05 00:00 [received]
PHST- 2013/06/05 00:00 [accepted]
PHST- 2013/07/25 06:00 [entrez]
PHST- 2013/07/25 06:00 [pubmed]
PHST- 2014/10/22 06:00 [medline]
AID - 10.1111/ene.12232 [doi]
PST - ppublish
SO  - Eur J Neurol. 2014;21(1):57-64. doi: 10.1111/ene.12232. Epub 2013 Jul 23.