PMID- 23880208
OWN - NLM
STAT- MEDLINE
DCOM- 20131107
LR  - 20220310
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 229
IP  - 2
DP  - 2013 Aug
TI  - Circulating osteopontin as a marker of early coronary vascular calcification in 
      type two diabetes mellitus patients with known asymptomatic coronary artery 
      disease.
PG  - 475-81
LID - S0021-9150(13)00367-5 [pii]
LID - 10.1016/j.atherosclerosis.2013.06.003 [doi]
AB  - OBJECTIVE: To evaluate the interrelation between circulating osteopontin (OPN) 
      and coronary atherosclerosis and calcification in type 2 diabetes mellitus 
      patients (T2DM). DESIGN AND METHODS: 126 subjects (46 patients with T2DM) with 
      previously documented asymptomatic coronary artery disease (CAD) were enrolled in 
      the study. CAD was determined by contrast multispiral CT-angiography. OPN plasma 
      levels were measured by ELISA. RESULTS: Analysis of the results showed that in a 
      patient cohort the mean value of circulating OPN was 43.55 ng/mL (95% CI = 
      31.5-57.0 ng/mL). OPN plasma levels were correlated with Agatston score index (r 
      = 0.418, P = 0.009), T2DM (r = 0.411, P = 0.006), gender (r = 0.395, P < 0.001 
      for male), TC (r = 0.405, P = 0.006), hsC-RP (r = 0.368, P = 0.008), age (r = 
      0.256, P = 0.001), smoking (r = 0.255, P = 0.001) and inversely to LVEF (r = 
      -0.579, P = 0.001). Cox-regression analyzes showed that in T2DM patients upper 
      quartile OPN compared with the lowest quartile are associated with Agatston score 
      index (adjusted OR = 3.23, 95% CI = 1.09-5.20; P = 0.044), numerous of damaged 
      coronary arteries (adjusted OR = 2.60, 95% CI = 1.10-9.20, P = 0.005). The 
      findings suggest that the predictive power of the model for asymptomatic CAD 
      patients with T2DM, the estimated AUC (area under curve) was 0.788. In this case, 
      the concentration of OPN that had the best predict potential on the risk of 
      coronary atherosclerosis was 48.5 ng/mL. In conclusions, we believe that elevated 
      OPN in plasma can be considered as an independent predictor of coronary 
      calcification in T2DM patients with known CAD.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Berezin, A E
AU  - Berezin AE
AD  - State Medical University, Internal Medicine Department, Zaporozhye, Ukraine. 
      dr_berezin@mail.ru
FAU - Kremzer, A A
AU  - Kremzer AA
LA  - eng
PT  - Journal Article
DEP - 20130625
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Biomarkers)
RN  - 106441-73-0 (Osteopontin)
SB  - IM
MH  - Biomarkers/blood
MH  - Cohort Studies
MH  - Coronary Artery Disease/*blood/epidemiology
MH  - Diabetes Mellitus, Type 2/*blood/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Osteopontin/*blood
MH  - Predictive Value of Tests
MH  - Proportional Hazards Models
MH  - Risk Assessment
MH  - Risk Factors
MH  - Vascular Calcification/*blood/epidemiology
OTO - NOTNLM
OT  - Artery calcification
OT  - Asymptomatic atherosclerosis
OT  - Osteopontin
OT  - Predicted value
OT  - Type 2 diabetes mellitus
EDAT- 2013/07/25 06:00
MHDA- 2013/11/08 06:00
CRDT- 2013/07/25 06:00
PHST- 2013/02/04 00:00 [received]
PHST- 2013/04/27 00:00 [revised]
PHST- 2013/06/02 00:00 [accepted]
PHST- 2013/07/25 06:00 [entrez]
PHST- 2013/07/25 06:00 [pubmed]
PHST- 2013/11/08 06:00 [medline]
AID - S0021-9150(13)00367-5 [pii]
AID - 10.1016/j.atherosclerosis.2013.06.003 [doi]
PST - ppublish
SO  - Atherosclerosis. 2013 Aug;229(2):475-81. doi: 
      10.1016/j.atherosclerosis.2013.06.003. Epub 2013 Jun 25.