PMID- 23880864
OWN - NLM
STAT- MEDLINE
DCOM- 20140211
LR  - 20211021
IS  - 1422-0067 (Print)
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 14
IP  - 7
DP  - 2013 Jul 22
TI  - Serum oxidant and antioxidant status following an all-out 21-km run in adolescent 
      runners undergoing professional training--a one-year prospective trial.
PG  - 15167-78
LID - 10.3390/ijms140715167 [doi]
AB  - This study investigated the 1-year longitudinal effect of professional training 
      in adolescent runners on redox balance during intense endurance exercise. Changes 
      in selected serum oxidant and antioxidant status in response to a 21-km running 
      time trial in 10 runners (15.5 +/- 1.3 years) undergoing professional training were 
      evaluated twice in 12 months (pre- and post-evaluation). Venous blood samples 
      were collected immediately before and 4-h following the 21-km run for analysis of 
      serum concentrations of thiobarbituric acid-reactive substances (TBARS), xanthine 
      oxidase (XO), catalase (CAT), reduced glutathione (GSH), superoxide dismutase 
      (SOD), and total antioxidant capacity (T-AOC). In pre-evaluation trial, serum 
      TBARS and SOD decreased after the 21-km run (p < 0.05) while XO, GSH, CAT and 
      TAOC were unchanged. In post-evaluation trial, serum TBARS and SOD decreased, 
      whereas XO and CAT increased post-exercise (p < 0.05). Furthermore, pre-exercise 
      serum T-AOC, post-exercise serum XO, CAT, T-AOC (p < 0.05), and GSH (p = 0.057) 
      appeared to be higher than the corresponding pre-evaluation values. The current 
      findings suggest that a professional training regime in adolescent runners is not 
      likely to jeopardize the development of their antioxidant defense. However, 
      uncertainties in the maintenance of redox balance in runners facing increased 
      exercise-induced oxidative stress as a consequence of training-induced 
      enhancement of exercise capacity await further elucidation.
FAU - Tong, Tom K
AU  - Tong TK
AD  - Dr. Stephen Hui Research Centre for Physical Recreation and Wellness, Department 
      of Physical Education, Hong Kong Baptist University, Hong Kong, China. 
      tongkk@hkbu.edu.hk
FAU - Kong, Zhaowei
AU  - Kong Z
FAU - Lin, Hua
AU  - Lin H
FAU - Lippi, Giuseppe
AU  - Lippi G
FAU - Zhang, Haifeng
AU  - Zhang H
FAU - Nie, Jinlei
AU  - Nie J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130722
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 1.17.3.2 (Xanthine Oxidase)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Adolescent
MH  - Catalase/*blood
MH  - Glutathione/*blood
MH  - Humans
MH  - Longitudinal Studies
MH  - Prospective Studies
MH  - Running
MH  - Superoxide Dismutase/*blood
MH  - Thiobarbituric Acid Reactive Substances/*analysis
MH  - Time Factors
MH  - Xanthine Oxidase/*blood
PMC - PMC3742293
EDAT- 2013/07/25 06:00
MHDA- 2014/02/12 06:00
PMCR- 2013/07/01
CRDT- 2013/07/25 06:00
PHST- 2013/06/06 00:00 [received]
PHST- 2013/07/03 00:00 [revised]
PHST- 2013/07/08 00:00 [accepted]
PHST- 2013/07/25 06:00 [entrez]
PHST- 2013/07/25 06:00 [pubmed]
PHST- 2014/02/12 06:00 [medline]
PHST- 2013/07/01 00:00 [pmc-release]
AID - ijms140715167 [pii]
AID - ijms-14-15167 [pii]
AID - 10.3390/ijms140715167 [doi]
PST - epublish
SO  - Int J Mol Sci. 2013 Jul 22;14(7):15167-78. doi: 10.3390/ijms140715167.