PMID- 23881360
OWN - NLM
STAT- MEDLINE
DCOM- 20140630
LR  - 20211021
IS  - 1559-0305 (Electronic)
IS  - 1073-6085 (Linking)
VI  - 55
IP  - 2
DP  - 2013 Oct
TI  - Role of RNA structure motifs in IRES-dependent translation initiation of the 
      coxsackievirus B3: new insights for developing live-attenuated strains for 
      vaccines and gene therapy.
PG  - 179-202
LID - 10.1007/s12033-013-9674-4 [doi]
AB  - Internal ribosome entry site (IRES) elements are highly structured RNA sequences 
      that function to recruit ribosomes for the initiation of translation. In contrast 
      to the canonical cap-binding, the mechanism of IRES-mediated translation 
      initiation is still poorly understood. Translation initiation of the 
      coxsackievirus B3 (CVB3), a causative agent of viral myocarditis, has been shown 
      to be mediated by a highly ordered structure of the 5' untranslated region 
      (5'UTR), which harbors an IRES. Taking into account that efficient initiation of 
      mRNA translation depends on temporally and spatially orchestrated sequence of 
      RNA-protein and RNA-RNA interactions, and that, at present, little is known about 
      these interactions, we aimed to describe recent advances in our understanding of 
      molecular structures and biochemical functions of the translation initiation 
      process. Thus, this review will explore the IRES elements as important RNA 
      structures and the significance of these structures in providing an alternative 
      mechanism of translation initiation of the CVB3 RNA. Since translation initiation 
      is the first intracellular step during the CVB3 infection cycle, the IRES region 
      provides an ideal target for antiviral therapies. Interestingly, the 5' and 
      3'UTRs represent promising candidates for the study of CVB3 cardiovirulence and 
      provide new insights for developing live-attenuated vaccines.
FAU - Souii, Amira
AU  - Souii A
AD  - Institut Superieur de Biotechnologie de Monastir-Universite de Monastir, Avenue 
      Tahar Hadded, BP 74, 5000, Monastir, Tunisia.
FAU - Ben M'hadheb-Gharbi, Manel
AU  - Ben M'hadheb-Gharbi M
FAU - Gharbi, Jawhar
AU  - Gharbi J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Switzerland
TA  - Mol Biotechnol
JT  - Molecular biotechnology
JID - 9423533
RN  - 0 (3' Untranslated Regions)
RN  - 0 (5' Untranslated Regions)
RN  - 0 (RNA, Viral)
RN  - 0 (Trans-Activators)
RN  - 0 (Viral Vaccines)
RN  - 0 (Virulence Factors)
SB  - IM
MH  - 3' Untranslated Regions
MH  - 5' Untranslated Regions
MH  - Enterovirus B, Human/*genetics/immunology/pathogenicity
MH  - *Genetic Therapy
MH  - Humans
MH  - Models, Molecular
MH  - Nucleic Acid Conformation
MH  - *Peptide Chain Initiation, Translational
MH  - RNA, Viral/*chemistry/*genetics
MH  - Ribosomes/genetics
MH  - Trans-Activators/genetics/physiology
MH  - Viral Vaccines/*genetics
MH  - Virulence Factors/chemistry/genetics
EDAT- 2013/07/25 06:00
MHDA- 2014/07/01 06:00
CRDT- 2013/07/25 06:00
PHST- 2013/07/25 06:00 [entrez]
PHST- 2013/07/25 06:00 [pubmed]
PHST- 2014/07/01 06:00 [medline]
AID - 10.1007/s12033-013-9674-4 [doi]
PST - ppublish
SO  - Mol Biotechnol. 2013 Oct;55(2):179-202. doi: 10.1007/s12033-013-9674-4.