PMID- 23883819
OWN - NLM
STAT- MEDLINE
DCOM- 20140620
LR  - 20131024
IS  - 1476-5470 (Electronic)
IS  - 1466-4879 (Linking)
VI  - 14
IP  - 7
DP  - 2013 Oct
TI  - Estradiol downregulates NF-kappab translocation by Ikbkg transcriptional repression 
      in dendritic cells.
PG  - 462-9
LID - 10.1038/gene.2013.35 [doi]
AB  - To reconcile immunity and reproduction, females must allow spermatozoa to survive 
      and control the presence of commensal microbiota and sexually transmitted 
      pathogens during ovulation. Female steroid sex hormones exert a powerful effect 
      on the immune system, as do the hormonal changes associated with the ovarian 
      cycle. Dendritic cells (DCs) are immunological sentinels that link innate 
      immunity to adaptive immunity. Upon exposure to microbial invaders in tissue, 
      they undergo a maturational process that culminates in the lymph nodes and 
      activates T-cell-specific immune responses. Estradiol, which is highly expressed 
      during ovulation, has an effect on the maturation of DCs, although the molecular 
      mechanism remains elusive. We detected that estradiol regulates expression of 
      Ikbkg in DCs and modulates nuclear factor-kappab translocation to the nucleus, thus 
      explaining the reduced DC function observed during ovulation. This change may be 
      an adaptive mechanism to reconcile control of infection and reproductive 
      functions.
FAU - Lasarte, S
AU  - Lasarte S
AD  - Laboratorio InmunoBiologia Molecular, Hospital General Universitario Gregorio 
      Maranon and Instituto de Investigacion Sanitaria Gregorio Maranon, Madrid, Spain.
FAU - Elsner, D
AU  - Elsner D
FAU - Sanchez-Elsner, T
AU  - Sanchez-Elsner T
FAU - Fernandez-Pineda, A
AU  - Fernandez-Pineda A
FAU - Lopez-Fernandez, L A
AU  - Lopez-Fernandez LA
FAU - Corbi, A L
AU  - Corbi AL
FAU - Munoz-Fernandez, M A
AU  - Munoz-Fernandez MA
FAU - Relloso, M
AU  - Relloso M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130725
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (NF-kappa B)
RN  - 4TI98Z838E (Estradiol)
RN  - EC 2.7.11.10 (I-kappa B Kinase)
SB  - IM
MH  - Active Transport, Cell Nucleus
MH  - Animals
MH  - Cell Nucleus/*metabolism
MH  - Cells, Cultured
MH  - Dendritic Cells/drug effects/*metabolism
MH  - Estradiol/*pharmacology
MH  - Female
MH  - I-kappa B Kinase/*metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - NF-kappa B/*metabolism
MH  - Transcription, Genetic
EDAT- 2013/07/26 06:00
MHDA- 2014/06/21 06:00
CRDT- 2013/07/26 06:00
PHST- 2013/01/28 00:00 [received]
PHST- 2013/05/08 00:00 [revised]
PHST- 2013/05/24 00:00 [accepted]
PHST- 2013/07/26 06:00 [entrez]
PHST- 2013/07/26 06:00 [pubmed]
PHST- 2014/06/21 06:00 [medline]
AID - gene201335 [pii]
AID - 10.1038/gene.2013.35 [doi]
PST - ppublish
SO  - Genes Immun. 2013 Oct;14(7):462-9. doi: 10.1038/gene.2013.35. Epub 2013 Jul 25.