PMID- 23884221
OWN - NLM
STAT- MEDLINE
DCOM- 20131112
LR  - 20210301
IS  - 1550-8080 (Electronic)
IS  - 0091-7370 (Linking)
VI  - 43
IP  - 3
DP  - 2013 Summer
TI  - Effect of routine heparins treatment in acute coronary syndrome on serum 
      pregnancy-associated plasma protein a concentration.
PG  - 274-7
AB  - BACKGROUND: Pregnancy-associated plasma protein A (PAPP-A) has been suggested as 
      a useful marker of acute coronary syndrome (ACS). Serum PAPP-A concentrations are 
      affected by unfractionated heparin (UFH) in ACS population, and we tried to 
      investigate the time profile of effects of routine heparins treatment on serum 
      PAPP-A concentrations in ACS population thoroughly and give advice to sample 
      collection of related study. METHODS: Twenty cases were involved in this study: 
      ten patients with acute myocardial infarction received subcutaneous low molecular 
      weight heparin (LMWH) twice a day (group A), and the other ten percutaneous 
      coronary intervention patients with stenting received intravenous UFH (group B). 
      Samples were collected before and after heparin administration and serum PAPP-A 
      concentrations were analyzed in these samples. RESULTS: Serum PAPP-A 
      concentration increased in both group A and B. In group A, PAPP-A concentration 
      elevated gradually (14.5 to 29.4 mIU/L, P<0.05) throughout the observation period 
      and normalized at 48h after drug discontinuation. In group B, there was a rapid 
      and intense increase after intravenous heparin injection (13.1 to 49.3 mIU/L, 
      P<0.05), and a new PAPP-A peak was induced by additional heparin administration. 
      CONCLUSIONS: Heparins-induced increase in serum PAPP-A concentration lasted until 
      48h after drug use was discontinued. We recommend that samples from these 
      patients for PAPP-A measurement should be collected at least 48h after the last 
      administration if its not available before the administration of heparins.
FAU - Wang, Guodong
AU  - Wang G
AD  - Department of Cardiology, Weifang People's Hospital, Weifang, Shandong, 261041, 
      P.R.China. guodongwang101@126.com
FAU - Zhang, Aiyuan
AU  - Zhang A
FAU - Han, Xiaoli
AU  - Han X
FAU - Zhang, Jungang
AU  - Zhang J
FAU - Zhang, Guangfang
AU  - Zhang G
FAU - Sun, Liping
AU  - Sun L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Ann Clin Lab Sci
JT  - Annals of clinical and laboratory science
JID - 0410247
RN  - 0 (Anticoagulants)
RN  - 0 (Biomarkers)
RN  - 9005-49-6 (Heparin)
RN  - EC 3.4.24.- (Pregnancy-Associated Plasma Protein-A)
RN  - EC 3.4.24.79 (PAPPA protein, human)
SB  - IM
MH  - Acute Coronary Syndrome/blood/diagnosis/*drug therapy
MH  - Aged
MH  - Anticoagulants/*administration & dosage
MH  - Biomarkers/*blood
MH  - Female
MH  - Heparin/*administration & dosage
MH  - Humans
MH  - Injections, Intravenous
MH  - Male
MH  - Middle Aged
MH  - Pregnancy-Associated Plasma Protein-A/*metabolism
MH  - Prognosis
MH  - Time Factors
OTO - NOTNLM
OT  - acute coronary syndrome
OT  - heparin
OT  - low-molecular-weight
OT  - pregnancy-associated plasma protein A
EDAT- 2013/07/26 06:00
MHDA- 2013/11/13 06:00
CRDT- 2013/07/26 06:00
PHST- 2013/07/26 06:00 [entrez]
PHST- 2013/07/26 06:00 [pubmed]
PHST- 2013/11/13 06:00 [medline]
AID - 43/3/274 [pii]
PST - ppublish
SO  - Ann Clin Lab Sci. 2013 Summer;43(3):274-7.