PMID- 23884433
OWN - NLM
STAT- MEDLINE
DCOM- 20140519
LR  - 20180816
IS  - 1473-5873 (Electronic)
IS  - 0955-8829 (Linking)
VI  - 23
IP  - 5
DP  - 2013 Oct
TI  - Effect of BDNF Val66Met and serotonin transporter 5-HTTLPR polymorphisms on 
      psychopathological characteristics in a sample of university students.
PG  - 188-97
LID - 10.1097/YPG.0b013e3283643629 [doi]
AB  - OBJECTIVE: The aims of this study were to evaluate the impact of the 
      brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on several 
      psychological characteristics in a group of Greek University students and to 
      explore putative interactions with the serotonin-transporter-linked polymorphic 
      region (5-HTTLPR) and serious past adverse experiences. METHODS: A total of 224 
      students were genotyped and classified as (a) carriers or noncarriers of the Met 
      allele of the BDNF Val66Met polymorphism and (b) carriers or noncarriers of the S 
      or Lg alleles (S') of the 5-HTTLPR polymorphism. Students were evaluated using a 
      battery of standard psychological tests and answered questionnaires on serious 
      past adverse experiences. RESULTS: The Val/Val BDNF genotype was associated with 
      higher scores in several psychopathological dimensions. When the effect of the 
      BDNF Met allele was examined in relation to 5-HTTLPR, it was restricted to S' 
      noncarriers. Among these students, BDNF Met allele carriers had lower scores 
      compared with noncarriers. The effects of the Met allele on the S' allele 
      noncarriers in the anxiety and phobic anxiety dimensions were more pronounced 
      among individuals who had reported no serious life adversities. CONCLUSION: There 
      may be a protective role of the BDNF Met allele in several psychopathological 
      features and it is suggested that some of these effects are moderated by 
      5-HTTLPR.
FAU - Kourmouli, Niki
AU  - Kourmouli N
AD  - Department of Biology, School of Medicine, Democritus University of Thrace, 
      Alexandroupolis, Greece.
FAU - Samakouri, Maria
AU  - Samakouri M
FAU - Mamatsiou, Athina
AU  - Mamatsiou A
FAU - Trypsianis, Gregory
AU  - Trypsianis G
FAU - Livaditis, Miltos
AU  - Livaditis M
FAU - Veletza, Stavroula
AU  - Veletza S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Psychiatr Genet
JT  - Psychiatric genetics
JID - 9106748
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (SLC6A4 protein, human)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antisocial Personality Disorder/*genetics
MH  - Anxiety/genetics
MH  - Brain-Derived Neurotrophic Factor/chemistry/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Multivariate Analysis
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics
MH  - Students/*psychology
MH  - *Universities
MH  - Young Adult
EDAT- 2013/07/26 06:00
MHDA- 2014/05/20 06:00
CRDT- 2013/07/26 06:00
PHST- 2013/07/26 06:00 [entrez]
PHST- 2013/07/26 06:00 [pubmed]
PHST- 2014/05/20 06:00 [medline]
AID - 10.1097/YPG.0b013e3283643629 [doi]
PST - ppublish
SO  - Psychiatr Genet. 2013 Oct;23(5):188-97. doi: 10.1097/YPG.0b013e3283643629.