PMID- 23884672
OWN - NLM
STAT- MEDLINE
DCOM- 20150526
LR  - 20181023
IS  - 1306-696X (Print)
IS  - 1306-696X (Linking)
VI  - 19
IP  - 4
DP  - 2013 Jul
TI  - Effects of combined and individual use of N-methyl-D aspartate receptor 
      antagonist magnesium sulphate and caspase-9 inhibitor z-LEDH-fmk in experimental 
      spinal cord injury.
PG  - 313-9
LID - 10.5505/tjtes.2013.45804 [doi]
AB  - BACKGROUND: We investigated the individual and combined effects of magnesium 
      sulphate, which is an N-Methyl-D aspartate receptor antagonist (NMDA), and 
      z-LEHD-FMK, which is a caspase 9 inhibitor, on the genesis of secondary injury in 
      a rat spinal cord injury model. We aimed to minimize the effects of secondary 
      injury in spinal cord trauma by choosing these two agents which served to block 
      the two major mechanisms of cell loss, apoptosis and necrosis. METHODS: The drugs 
      were given to the subjects according to their groups, either in singular or 
      combined fashion. For motor examination, the subjects were kept under close 
      clinical evaluation for five days. Histopathological examination and the emerging 
      spinal cord samples were prepared with haematoxylene-eosin and Tunel techniques. 
      RESULTS: A statistically significant difference in favor of the treatment groups 
      has been found between the treatment and control groups in terms of histological 
      data. However, there was no difference in the evaluation of motor examination 
      between trauma and treatment groups. CONCLUSION: We have found no difference 
      between the individual and combined uses of MgSO4 and z-LEHD-FMK in the 
      prevention of secondary injury; however, there were better histological results 
      in the treatment groups compared to trauma and control groups which gives us hope 
      for future investigations.
FAU - Sencer, Altay
AU  - Sencer A
AD  - Department of Neurosurgery, IU Istanbul Faculty of Medicine, Istanbul, Turkey.
FAU - Aydoseli, Aydin
AU  - Aydoseli A
FAU - Aras, Yavuz
AU  - Aras Y
FAU - Akcakaya, Mehmet Osman
AU  - Akcakaya MO
FAU - Gomleksiz, Cengiz
AU  - Gomleksiz C
FAU - Can, Halil
AU  - Can H
FAU - Canbolat, Ali
AU  - Canbolat A
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Ulus Travma Acil Cerrahi Derg
JT  - Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency 
      surgery : TJTES
JID - 101274231
RN  - 0 (Caspase Inhibitors)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Oligopeptides)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone)
RN  - 7487-88-9 (Magnesium Sulfate)
SB  - IM
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Caspase Inhibitors/*pharmacology
MH  - Disease Models, Animal
MH  - Magnesium Sulfate/*pharmacology
MH  - Male
MH  - Necrosis/pathology
MH  - Neuroprotective Agents/*pharmacology
MH  - Oligopeptides/*pharmacology
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors
MH  - Spinal Cord Injuries/*drug therapy/*pathology
EDAT- 2013/07/26 06:00
MHDA- 2015/05/27 06:00
CRDT- 2013/07/26 06:00
PHST- 2013/07/26 06:00 [entrez]
PHST- 2013/07/26 06:00 [pubmed]
PHST- 2015/05/27 06:00 [medline]
AID - 10.5505/tjtes.2013.45804 [doi]
PST - ppublish
SO  - Ulus Travma Acil Cerrahi Derg. 2013 Jul;19(4):313-9. doi: 
      10.5505/tjtes.2013.45804.