PMID- 23885076
OWN - NLM
STAT- MEDLINE
DCOM- 20131227
LR  - 20211021
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Print)
IS  - 0022-538X (Linking)
VI  - 87
IP  - 19
DP  - 2013 Oct
TI  - Herpesvirus 6 glycoproteins B (gB), gH, gL, and gQ are necessary and sufficient 
      for cell-to-cell fusion.
PG  - 10900-3
LID - 10.1128/JVI.01427-13 [doi]
AB  - The human herpesvirus 6 (HHV-6) envelope glycoprotein gH/gL/gQ1/gQ2 complex 
      associates with host cell CD46 as its cellular receptor. Although gB has been 
      suggested to be involved in HHV-6 infection, its function in membrane fusion has 
      remained unclear. Here, we have developed an HHV-6A (strain GS)and HHV-6B (strain 
      Z29) virus-free cell-to-cell fusion assay and demonstrate that gB and the 
      gH/gL/gQ1/gQ2 complex are the minimum components required for membrane fusion by 
      HHV-6.
FAU - Tanaka, Yuki
AU  - Tanaka Y
AD  - Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka 
      University, Osaka, Japan.
FAU - Suenaga, Tadahiro
AU  - Suenaga T
FAU - Matsumoto, Misako
AU  - Matsumoto M
FAU - Seya, Tsukasa
AU  - Seya T
FAU - Arase, Hisashi
AU  - Arase H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130724
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (DNA, Viral)
RN  - 0 (Glycoproteins)
RN  - 0 (Membrane Cofactor Protein)
RN  - EC 1.13.12.- (Luciferases)
SB  - IM
MH  - *Cell Fusion
MH  - Cells, Cultured
MH  - DNA, Viral/genetics
MH  - Flow Cytometry
MH  - Glycoproteins/classification/genetics/*metabolism
MH  - Herpesviridae Infections/genetics/*metabolism/virology
MH  - Herpesvirus 6, Human/*physiology
MH  - Humans
MH  - Kidney/cytology/metabolism/virology
MH  - Luciferases/metabolism
MH  - Membrane Cofactor Protein/genetics/*metabolism
MH  - *Membrane Fusion
MH  - Polymerase Chain Reaction
PMC - PMC3807422
EDAT- 2013/07/26 06:00
MHDA- 2013/12/29 06:00
PMCR- 2014/04/01
CRDT- 2013/07/26 06:00
PHST- 2013/07/26 06:00 [entrez]
PHST- 2013/07/26 06:00 [pubmed]
PHST- 2013/12/29 06:00 [medline]
PHST- 2014/04/01 00:00 [pmc-release]
AID - JVI.01427-13 [pii]
AID - 01427-13 [pii]
AID - 10.1128/JVI.01427-13 [doi]
PST - ppublish
SO  - J Virol. 2013 Oct;87(19):10900-3. doi: 10.1128/JVI.01427-13. Epub 2013 Jul 24.