PMID- 23886304
OWN - NLM
STAT- MEDLINE
DCOM- 20160512
LR  - 20211203
IS  - 1520-5762 (Electronic)
IS  - 0363-9045 (Linking)
VI  - 40
IP  - 10
DP  - 2014 Oct
TI  - In vitro skin permeation and anti-atopic efficacy of lipid nanocarriers 
      containing water soluble extracts of Houttuynia cordata.
PG  - 1350-7
LID - 10.3109/03639045.2013.819883 [doi]
AB  - OBJECTIVE: The aims of this work are to enhance the in vitro skin permeation of 
      Houttuynia cordata (water-soluble extract of H. cordata; HCWSE) and to boost the 
      efficacy of HCWSE against atopic dermatitis (AD) - like skin lesion in hairless 
      mice using lipid nano-carriers (liposome and cubosome). METHODS: HCWSE was 
      obtained by a hot water extraction. Monoolein cubosomal suspension containing 
      HCWSE and egg phosphatidylcholine liposomal suspension containing the same was 
      prepared by a sonication and a film hydration method, respectively. RESULTS: The 
      lipid nano-carriers, especially cubosome, enhanced the in vitro skin permeation 
      of HCWSE. The inhibitory effects of HCWSE-containing lipid carrier suspensions on 
      the development of 1-chloro-2,4-dinitrobenzene (DNCB)-induced AD-like skin lesion 
      in hairless mice were investigated by observing appearance of skin surface, serum 
      immunoglobulin E (IgE) level and cytokine expression. HCWSE-containing 
      preparations suppressed IgE production and interleukin 4 expression, whereas they 
      promoted interferon gamma expression. The order of lymphocyte (B-cell, Th1 cell 
      and Th2 cell) modulating effect was HCWSE-containing cubosomal 
      suspension > HCWSE-containing liposomal suspension > HCWSE solution in phosphate 
      buffered saline, indicating that the cubosomal suspension, among the 
      preparations, was the most efficacious in inhibiting the development of 
      DNCB-induced AD-like skin lesion. CONCLUSION: It is believed that the cubosomal 
      suspension containing HCWSE would be an efficacious preparation for the treatment 
      of AD.
FAU - Kwon, Taek Kwan
AU  - Kwon TK
AD  - Division of Biotechnology & Bioengineering, Institute of Bioscience and 
      Biotechnology, Kangwon National University , Chunchon , Republic of Korea.
FAU - Kim, Jin-Chul
AU  - Kim JC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130725
PL  - England
TA  - Drug Dev Ind Pharm
JT  - Drug development and industrial pharmacy
JID - 7802620
RN  - 0 (Cytokines)
RN  - 0 (Dinitrochlorobenzene)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Houttuynia cordata extract)
RN  - 0 (Lipids)
RN  - 0 (Liposomes)
RN  - 059QF0KO0R (Water)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/metabolism
MH  - Cytokines/metabolism
MH  - Dermatitis, Atopic/*drug therapy/pathology
MH  - Dinitrochlorobenzene/toxicity
MH  - Disease Models, Animal
MH  - Drugs, Chinese Herbal/*administration & dosage/pharmacokinetics/pharmacology
MH  - Female
MH  - Houttuynia
MH  - Immunoglobulin E/blood
MH  - Lipids/chemistry
MH  - Liposomes
MH  - Mice
MH  - Mice, Hairless
MH  - *Nanoparticles
MH  - *Skin Absorption
MH  - Th1 Cells/metabolism
MH  - Th2 Cells/metabolism
MH  - Water/chemistry
OTO - NOTNLM
OT  - Atopic dermatitis
OT  - Houttuynia cordata
OT  - cubosome
OT  - cytokines
OT  - immunoglobulin E
OT  - liposome
EDAT- 2013/07/28 06:00
MHDA- 2016/05/14 06:00
CRDT- 2013/07/27 06:00
PHST- 2013/07/27 06:00 [entrez]
PHST- 2013/07/28 06:00 [pubmed]
PHST- 2016/05/14 06:00 [medline]
AID - 10.3109/03639045.2013.819883 [doi]
PST - ppublish
SO  - Drug Dev Ind Pharm. 2014 Oct;40(10):1350-7. doi: 10.3109/03639045.2013.819883. 
      Epub 2013 Jul 25.