PMID- 23888080
OWN - NLM
STAT- MEDLINE
DCOM- 20131122
LR  - 20131004
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
VI  - 208
IP  - 9
DP  - 2013 Nov 1
TI  - Downregulation of IL7R, CCR7, and TLR4 in the cord blood of children with 
      respiratory syncytial virus disease.
PG  - 1431-5
LID - 10.1093/infdis/jit336 [doi]
AB  - The association between gene expression at birth of 11 candidate genes with 
      important innate and adaptive immune functions and later respiratory syncytial 
      virus (RSV) disease was investigated. Cord blood was collected from 2108 
      newborns. Forty-seven were subsequently RSV positive. Gene expression analysis by 
      quantitative reverse transcription-polymerase chain reaction was compared to 17 
      controls. There was downregulation of interleukin 7 receptor (IL7R) (P = .0001) 
      and chemokine receptor 7 (CCR7) (P = .002), and in the severe disease 
      subcategory, downregulation of Toll-like receptor 4 (TLR4) (P = .003). IL7R and 
      CCR7 facilitate communication between adaptive and innate immune systems. TLR4 
      activates the innate immune system on RSV exposure. Delayed innate and adaptive 
      immune activation may predispose children to more severe RSV disease.
FAU - Inchley, Christopher S
AU  - Inchley CS
AD  - Department of Pediatric and Adolescent Medicine, Akershus University Hospital, 
      Lorenskog.
FAU - Osterholt, Helene C D
AU  - Osterholt HC
FAU - Sonerud, Tonje
AU  - Sonerud T
FAU - Fjaerli, Hans O
AU  - Fjaerli HO
FAU - Nakstad, Britt
AU  - Nakstad B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130725
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (CCR7 protein, human)
RN  - 0 (Receptors, CCR7)
RN  - 0 (Receptors, Interleukin-7)
RN  - 0 (TLR4 protein, human)
RN  - 0 (Toll-Like Receptor 4)
SB  - IM
MH  - Adaptive Immunity
MH  - Case-Control Studies
MH  - Child, Preschool
MH  - Down-Regulation/immunology
MH  - Female
MH  - Fetal Blood/metabolism/virology
MH  - Gene Expression
MH  - Humans
MH  - Immunity, Innate
MH  - Infant
MH  - Infant, Newborn
MH  - Lymphocytes/immunology/virology
MH  - Male
MH  - Receptors, CCR7/*genetics/metabolism
MH  - Receptors, Interleukin-7/*genetics/metabolism
MH  - Respiratory Syncytial Virus Infections/*blood/immunology
MH  - Respiratory Syncytial Viruses/*immunology
MH  - Toll-Like Receptor 4/*genetics/metabolism
OTO - NOTNLM
OT  - CCR7
OT  - IL7
OT  - IL7R
OT  - TLR4
OT  - children
OT  - dendritic cells
OT  - gene expression
OT  - immunity
OT  - lymphocytes
OT  - respiratory syncytial virus
EDAT- 2013/07/28 06:00
MHDA- 2013/12/16 06:00
CRDT- 2013/07/27 06:00
PHST- 2013/07/27 06:00 [entrez]
PHST- 2013/07/28 06:00 [pubmed]
PHST- 2013/12/16 06:00 [medline]
AID - jit336 [pii]
AID - 10.1093/infdis/jit336 [doi]
PST - ppublish
SO  - J Infect Dis. 2013 Nov 1;208(9):1431-5. doi: 10.1093/infdis/jit336. Epub 2013 Jul 
      25.